SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lui'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2lui PICK1 PDZ DOMAIN
FUSED TO THE C10 DAT
LIGAND
(Rattus
norvegicus) 		5 / 12 ILE A  49
ILE A  35
ILE A  33
VAL A  23
LEU A  25
 None
 1.01A 1qhyA-2luiA:
undetectable		 1qhyA-2luiA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2lui PICK1 PDZ DOMAIN
FUSED TO THE C10 DAT
LIGAND
(Rattus
norvegicus) 		4 / 8 ASP A  68
GLY A  62
ALA A  58
ILE A  99
 None
 0.83A 2dtjA-2luiA:
undetectable
2dtjB-2luiA:
undetectable		 2dtjA-2luiA:
22.60
2dtjB-2luiA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2lui PICK1 PDZ DOMAIN
FUSED TO THE C10 DAT
LIGAND
(Rattus
norvegicus) 		5 / 12 ILE A  99
LEU A  60
GLN A  51
LEU A  32
VAL A  97
 None
 1.19A 3ix9B-2luiA:
undetectable		 3ix9B-2luiA:
23.56