SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DTL_A_BEPA204_1 (CARDIAC TROPONIN C)	2lv7	CALCIUM-BINDING PROTEIN 7 (Homo sapiens)	5 / 11	PHE A 42 ILE A 53 LEU A 58 MET A 62 LEU A 65	None	1.03A	1dtlA-2lv7A: 7.7	1dtlA-2lv7A: 21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1LXF_C_BEPC92_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	2lv7	CALCIUM-BINDING PROTEIN 7 (Homo sapiens)	6 / 12	PHE A 42 ILE A 53 LEU A 58 LEU A 65 ILE A 78 VAL A 89	None None None None None CA A 202 ( 4.2A)	1.07A	1lxfC-2lv7A: 6.8	1lxfC-2lv7A: 34.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP6_B_SALB3004_1 (TRANSCRIPTIONAL REGULATOR TCAR)	2lv7	CALCIUM-BINDING PROTEIN 7 (Homo sapiens)	4 / 5	ILE A 38 PHE A 91 ASP A 90 GLU A 93	None None CA A 202 (-4.2A) CA A 202 (-2.4A)	1.14A	3kp6A-2lv7A: undetectable 3kp6B-2lv7A: undetectable	3kp6A-2lv7A: 21.43 3kp6B-2lv7A: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XE5_A_OBNA1104_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	2lv7	CALCIUM-BINDING PROTEIN 7 (Homo sapiens)	5 / 12	GLU A 92 GLU A 93 LEU A 98 ALA A 41 ASP A 86	None CA A 202 (-2.4A) None None CA A 202 (-3.2A)	1.29A	4xe5A-2lv7A: undetectable	4xe5A-2lv7A: 6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IMS_B_ACTB713_0 (ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL)	2lv7	CALCIUM-BINDING PROTEIN 7 (Homo sapiens)	3 / 3	GLY A 51 GLN A 88 LYS A 43	None CA A 201 ( 4.2A) None	0.99A	5imsB-2lv7A: undetectable	5imsB-2lv7A: 10.28

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DTL_A_BEPA204_1","CARDIAC TROPONIN C","2lv7","CALCIUM-BINDING PROTEIN 7","Homo sapiens",5,"PHE A  42;ILE A  53;LEU A  58;MET A  62;LEU A  65","None","1.03A","1dtlA-2lv7A:7.7","1dtlA-2lv7A:21.91"],["1LXF_C_BEPC92_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","2lv7","CALCIUM-BINDING PROTEIN 7","Homo sapiens",6,"PHE A  42;ILE A  53;LEU A  58;LEU A  65;ILE A  78;VAL A  89","None;None;None;None;None; CA A 202 ( 4.2A)","1.07A","1lxfC-2lv7A:6.8","1lxfC-2lv7A:34.31"],["3KP6_B_SALB3004_1","TRANSCRIPTIONAL REGULATOR TCAR;TRANSCRIPTIONAL REGULATOR TCAR","2lv7","CALCIUM-BINDING PROTEIN 7","Homo sapiens",4,"ILE A  38;PHE A  91;ASP A  90;GLU A  93","None;None; CA A 202 (-4.2A); CA A 202 (-2.4A)","1.14A","3kp6A-2lv7A:undetectable;3kp6B-2lv7A:undetectable","3kp6A-2lv7A:21.43;3kp6B-2lv7A:21.43"],["4XE5_A_OBNA1104_1","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","2lv7","CALCIUM-BINDING PROTEIN 7","Homo sapiens",5,"GLU A  92;GLU A  93;LEU A  98;ALA A  41;ASP A  86","None; CA A 202 (-2.4A);None;None; CA A 202 (-3.2A)","1.29A","4xe5A-2lv7A:undetectable","4xe5A-2lv7A:6.82"],["5IMS_B_ACTB713_0","ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL","2lv7","CALCIUM-BINDING PROTEIN 7","Homo sapiens",3,"GLY A  51;GLN A  88;LYS A  43","None; CA A 201 ( 4.2A);None","0.99A","5imsB-2lv7A:undetectable","5imsB-2lv7A:10.28"]]