SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lvv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24
(Trypanosoma
brucei) 		5 / 9 GLY A 146
SER A 147
LEU A 149
ASP A 145
GLU A 154
 None
 1.47A 2j2pB-2lvvA:
undetectable
2j2pC-2lvvA:
undetectable		 2j2pB-2lvvA:
19.58
2j2pC-2lvvA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24
(Trypanosoma
brucei) 		4 / 7 VAL A 197
TYR A 128
ILE A  93
ASP A 190
 None
 1.13A 2x45B-2lvvA:
undetectable		 2x45B-2lvvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24
(Trypanosoma
brucei) 		4 / 7 VAL A 197
TYR A 128
ILE A  93
ASP A 190
 None
 1.15A 2x45C-2lvvA:
undetectable		 2x45C-2lvvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24
(Trypanosoma
brucei) 		3 / 3 LEU A 126
ARG A  52
ILE A 129
 None
 0.69A 2xn5B-2lvvA:
undetectable		 2xn5B-2lvvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24
(Trypanosoma
brucei) 		5 / 12 GLY A  76
CYH A  77
ILE A  41
LEU A 126
LEU A  90
 None
 1.29A 3cs8A-2lvvA:
undetectable		 3cs8A-2lvvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24
(Trypanosoma
brucei) 		5 / 12 LEU A  68
VAL A  73
CYH A  77
ILE A  37
LEU A 126
 None
 1.28A 3sp9B-2lvvA:
undetectable		 3sp9B-2lvvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24
(Trypanosoma
brucei) 		5 / 12 LEU A 150
LEU A 152
ASN A 177
ALA A 172
ILE A 169
 None
 1.17A 4x1yB-2lvvA:
undetectable		 4x1yB-2lvvA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24
(Trypanosoma
brucei) 		5 / 12 LEU A 150
LEU A 152
ASN A 177
ALA A 172
ILE A 169
 None
 1.20A 5eypB-2lvvA:
undetectable		 5eypB-2lvvA:
19.24