SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CMC_A_SAMA105_0 (MET REPRESSOR)	2lw1	ABC TRANSPORTER ATP-BINDING PROTEIN UUP (Escherichia coli)	5 / 10	ALA A 621 GLU A 569 LEU A 628 LEU A 577 PRO A 574	None	1.30A	1cmcA-2lw1A: undetectable 1cmcB-2lw1A: undetectable	1cmcA-2lw1A: 26.09 1cmcB-2lw1A: 26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJO_C_SAMC200_0 (METHIONINE REPRESSOR)	2lw1	ABC TRANSPORTER ATP-BINDING PROTEIN UUP (Escherichia coli)	5 / 12	ALA A 621 GLU A 569 LEU A 628 LEU A 577 PRO A 574	None	1.27A	1mjoC-2lw1A: undetectable 1mjoD-2lw1A: undetectable	1mjoC-2lw1A: 27.59 1mjoD-2lw1A: 27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_A_SAMA200_0 (METHIONINE REPRESSOR)	2lw1	ABC TRANSPORTER ATP-BINDING PROTEIN UUP (Escherichia coli)	5 / 11	GLU A 569 LEU A 628 LEU A 577 PRO A 574 ALA A 621	None	1.32A	1mjqA-2lw1A: undetectable 1mjqB-2lw1A: undetectable	1mjqA-2lw1A: 27.59 1mjqB-2lw1A: 27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_C_SAMC199_0 (METHIONINE REPRESSOR)	2lw1	ABC TRANSPORTER ATP-BINDING PROTEIN UUP (Escherichia coli)	5 / 10	GLU A 569 LEU A 628 LEU A 577 PRO A 574 ALA A 621	None	1.29A	1mjqC-2lw1A: undetectable 1mjqD-2lw1A: undetectable	1mjqC-2lw1A: 27.59 1mjqD-2lw1A: 27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_I_SAMI199_0 (METHIONINE REPRESSOR)	2lw1	ABC TRANSPORTER ATP-BINDING PROTEIN UUP (Escherichia coli)	5 / 11	GLU A 569 LEU A 628 LEU A 577 PRO A 574 ALA A 621	None	1.28A	1mjqI-2lw1A: undetectable 1mjqJ-2lw1A: undetectable	1mjqI-2lw1A: 27.59 1mjqJ-2lw1A: 27.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CMC_A_SAMA105_0","MET REPRESSOR","2lw1","ABC TRANSPORTER ATP-BINDING PROTEIN UUP","Escherichia coli",5,"ALA A 621;GLU A 569;LEU A 628;LEU A 577;PRO A 574","None","1.30A","1cmcA-2lw1A:undetectable;1cmcB-2lw1A:undetectable","1cmcA-2lw1A:26.09;1cmcB-2lw1A:26.09"],["1MJO_C_SAMC200_0","METHIONINE REPRESSOR","2lw1","ABC TRANSPORTER ATP-BINDING PROTEIN UUP","Escherichia coli",5,"ALA A 621;GLU A 569;LEU A 628;LEU A 577;PRO A 574","None","1.27A","1mjoC-2lw1A:undetectable;1mjoD-2lw1A:undetectable","1mjoC-2lw1A:27.59;1mjoD-2lw1A:27.59"],["1MJQ_A_SAMA200_0","METHIONINE REPRESSOR","2lw1","ABC TRANSPORTER ATP-BINDING PROTEIN UUP","Escherichia coli",5,"GLU A 569;LEU A 628;LEU A 577;PRO A 574;ALA A 621","None","1.32A","1mjqA-2lw1A:undetectable;1mjqB-2lw1A:undetectable","1mjqA-2lw1A:27.59;1mjqB-2lw1A:27.59"],["1MJQ_C_SAMC199_0","METHIONINE REPRESSOR","2lw1","ABC TRANSPORTER ATP-BINDING PROTEIN UUP","Escherichia coli",5,"GLU A 569;LEU A 628;LEU A 577;PRO A 574;ALA A 621","None","1.29A","1mjqC-2lw1A:undetectable;1mjqD-2lw1A:undetectable","1mjqC-2lw1A:27.59;1mjqD-2lw1A:27.59"],["1MJQ_I_SAMI199_0","METHIONINE REPRESSOR","2lw1","ABC TRANSPORTER ATP-BINDING PROTEIN UUP","Escherichia coli",5,"GLU A 569;LEU A 628;LEU A 577;PRO A 574;ALA A 621","None","1.28A","1mjqI-2lw1A:undetectable;1mjqJ-2lw1A:undetectable","1mjqI-2lw1A:27.59;1mjqJ-2lw1A:27.59"]]