SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2lw7 HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 GLY A 128
ILE A 127
SER A  76
GLN A 112
 None
 0.88A 2a8tB-2lw7A:
undetectable		 2a8tB-2lw7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2lw7 HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 LEU A 155
VAL A 136
LEU A 132
LEU A 139
LEU A  88
 None
 1.32A 4or0B-2lw7A:
undetectable		 4or0B-2lw7A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2lw7 HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 4 ARG A  16
GLY A  14
GLU A  33
 None
 0.66A 4z2dB-2lw7A:
undetectable
4z2dC-2lw7A:
undetectable		 4z2dB-2lw7A:
16.80
4z2dC-2lw7A:
20.73