SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 2lwe PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		3 / 3 LYS A 108
ARG A 161
VAL A 156
 None
 1.00A 2r2vC-2lweA:
undetectable
2r2vD-2lweA:
undetectable		 2r2vC-2lweA:
13.48
2r2vD-2lweA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2lwe PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 10 ILE A 118
PHE A 114
ILE A 124
SER A 128
LEU A 159
 None
 1.23A 3o1cA-2lweA:
undetectable		 3o1cA-2lweA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 2lwe PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 9 ILE A 123
ILE A 124
LEU A 155
LEU A 171
ALA A 174
 None
 1.08A 3ozvB-2lweA:
undetectable		 3ozvB-2lweA:
14.61