SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2lwj TRANSCRIPTIONAL
REGULATOR, CARD
FAMILY
(Myxococcus
xanthus) 		4 / 4 MET A 133
ALA A 137
TYR A  98
ILE A 102
 None
 1.46A 1upfD-2lwjA:
undetectable		 1upfD-2lwjA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 2lwj TRANSCRIPTIONAL
REGULATOR, CARD
FAMILY
(Myxococcus
xanthus) 		5 / 12 GLY A 129
GLU A 130
LEU A 120
ASP A 116
ASN A  92
 None
 1.17A 1xdsB-2lwjA:
undetectable		 1xdsB-2lwjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2lwj TRANSCRIPTIONAL
REGULATOR, CARD
FAMILY
(Myxococcus
xanthus) 		4 / 8 LEU A 160
ILE A 163
LEU A 145
ILE A 142
 None
 0.95A 2azxA-2lwjA:
undetectable		 2azxA-2lwjA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2lwj TRANSCRIPTIONAL
REGULATOR, CARD
FAMILY
(Myxococcus
xanthus) 		3 / 3 LYS A  13
LYS A 143
SER A 146
 None
 0.88A 5odiA-2lwjA:
undetectable		 5odiA-2lwjA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2lwj TRANSCRIPTIONAL
REGULATOR, CARD
FAMILY
(Myxococcus
xanthus) 		3 / 3 GLU A  97
ARG A  94
TYR A  98
 None
 0.63A 5trqB-2lwjA:
undetectable		 5trqB-2lwjA:
20.71