SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 159
LEU A  73
PRO A 164
ALA A 140
PHE A 112
 None
 1.19A 1gseA-2lxnA:
2.4		 1gseA-2lxnA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		5 / 8 ASP A 106
ALA A 140
ILE A 175
GLY A 172
PRO A 116
 None
 1.25A 1sguA-2lxnA:
undetectable		 1sguA-2lxnA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A  38
ASN A  67
ILE A  64
ASP A  63
 None
 1.05A 2h4jA-2lxnA:
4.1		 2h4jA-2lxnA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		5 / 6 LEU A   5
VAL A   3
LYS A  27
ILE A  47
ILE A  64
 None
 1.22A 2piwA-2lxnA:
undetectable		 2piwA-2lxnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A  68
GLY A 159
LYS A 151
HIS A 152
 None
 1.49A 2yldA-2lxnA:
undetectable		 2yldA-2lxnA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A  68
GLY A 159
LYS A 151
HIS A 152
 None
 1.50A 3zwiA-2lxnA:
undetectable		 3zwiA-2lxnA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  46
GLY A 184
LEU A  19
ILE A  47
LEU A  73
 None
 1.09A 4fr0A-2lxnA:
undetectable		 4fr0A-2lxnA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A  20
TYR A  21
ARG A  17
 None
 1.14A 4gc9A-2lxnA:
undetectable		 4gc9A-2lxnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  47
LEU A   5
ILE A  82
GLY A  51
 None
 0.83A 4hb8A-2lxnA:
undetectable		 4hb8A-2lxnA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		4 / 6 CYH A  76
GLY A   8
GLY A   9
ASP A   6
 None
 0.74A 5a06D-2lxnA:
4.2		 5a06D-2lxnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  74
GLY A  91
VAL A 129
GLY A  52
GLY A  51
 None
 0.90A 5koxA-2lxnA:
undetectable		 5koxA-2lxnA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		5 / 12 MET A 150
LEU A 111
ILE A 175
VAL A 103
PHE A 119
 None
 1.44A 5vlmE-2lxnA:
undetectable		 5vlmE-2lxnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Methanocaldococc
us
jannaschii) 		3 / 3 GLN A 146
ILE A  75
HIS A 163
 None
 0.64A 5z12B-2lxnA:
undetectable		 5z12B-2lxnA:
19.68