SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2lxp UBIQUITIN-CONJUGATIN
G ENZYME E2 G2
(Homo
sapiens) 		4 / 7 MET A  71
ILE A  41
GLY A  27
MET A  29
 None
 1.09A 2pnjB-2lxpA:
undetectable		 2pnjB-2lxpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 2lxp UBIQUITIN-CONJUGATIN
G ENZYME E2 G2
(Homo
sapiens) 		4 / 5 ASN A  33
LEU A  16
GLY A  27
THR A  74
 None
 0.88A 3dl9A-2lxpA:
undetectable		 3dl9A-2lxpA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2lxp E3 UBIQUITIN-PROTEIN
LIGASE AMFR
(Homo
sapiens) 		3 / 3 PHE C 360
CYH C 375
HIS C 358
 None
ZN  C 901 (-2.2A)
ZN  C 901 (-2.9A)
 1.29A 3u9fL-2lxpC:
undetectable		 3u9fL-2lxpC:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2lxp UBIQUITIN-CONJUGATIN
G ENZYME E2 G2
(Homo
sapiens) 		5 / 10 LEU A 120
LEU A  58
ALA A  26
LEU A   9
LEU A  16
 None
 0.93A 4p65A-2lxpA:
undetectable
4p65B-2lxpA:
undetectable
4p65F-2lxpA:
undetectable
4p65H-2lxpA:
undetectable		 4p65A-2lxpA:
11.30
4p65B-2lxpA:
12.30
4p65F-2lxpA:
12.30
4p65H-2lxpA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2lxp UBIQUITIN-CONJUGATIN
G ENZYME E2 G2
(Homo
sapiens) 		5 / 11 LEU A 120
LEU A  58
ALA A  26
LEU A  16
LEU A   9
 None
 0.95A 4p65C-2lxpA:
undetectable
4p65D-2lxpA:
undetectable
4p65J-2lxpA:
undetectable
4p65L-2lxpA:
undetectable		 4p65C-2lxpA:
11.30
4p65D-2lxpA:
12.30
4p65J-2lxpA:
12.30
4p65L-2lxpA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 2lxp UBIQUITIN-CONJUGATIN
G ENZYME E2 G2
(Homo
sapiens) 		5 / 11 LEU A 120
LEU A  58
ALA A  26
LEU A   9
LEU A  16
 None
 0.93A 4p65E-2lxpA:
undetectable
4p65F-2lxpA:
undetectable
4p65J-2lxpA:
undetectable
4p65L-2lxpA:
undetectable		 4p65E-2lxpA:
11.30
4p65F-2lxpA:
12.30
4p65J-2lxpA:
12.30
4p65L-2lxpA:
12.30