SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2lxx ACTIN-DEPOLYMERIZING
FACTOR 2, ISOFORM C
(Caenorhabditis
elegans) 		4 / 7 PHE A  29
ALA A  14
ALA A  71
PHE A  94
 None
 0.87A 2vcvL-2lxxA:
undetectable		 2vcvL-2lxxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2lxx ACTIN-DEPOLYMERIZING
FACTOR 2, ISOFORM C
(Caenorhabditis
elegans) 		4 / 8 TYR A  69
ILE A  31
ILE A  38
ALA A 116
 None
 0.96A 4ou1A-2lxxA:
undetectable		 4ou1A-2lxxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2lxx ACTIN-DEPOLYMERIZING
FACTOR 2, ISOFORM C
(Caenorhabditis
elegans) 		4 / 7 LEU A  18
ALA A  70
LEU A 121
ILE A  28
 None
 0.76A 4ubsA-2lxxA:
undetectable		 4ubsA-2lxxA:
16.67