SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lyi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 2lyi PROTEIN (ENTITY)
(Nephila
antipodiana) 		4 / 7 LEU A  43
LEU A 114
SER A 111
VAL A  98
 None
 1.02A 1dvxB-2lyiA:
undetectable		 1dvxB-2lyiA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 2lyi PROTEIN (ENTITY)
(Nephila
antipodiana) 		4 / 5 GLY A   5
LEU A   8
THR A   9
VAL A  93
 None
 0.96A 1ekjF-2lyiA:
undetectable
1ekjG-2lyiA:
undetectable		 1ekjF-2lyiA:
24.24
1ekjG-2lyiA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2lyi PROTEIN (ENTITY)
(Nephila
antipodiana) 		4 / 8 LEU A 110
VAL A  64
VAL A  56
VAL A  98
 None
 1.00A 2bdmA-2lyiA:
undetectable		 2bdmA-2lyiA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lyi PROTEIN (ENTITY)
(Nephila
antipodiana) 		4 / 7 ILE A  84
GLY A  42
VAL A 141
LEU A  92
 None
 0.92A 3elzA-2lyiA:
undetectable		 3elzA-2lyiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 2lyi PROTEIN (ENTITY)
(Nephila
antipodiana) 		5 / 12 THR A  21
LEU A  92
SER A  88
VAL A 106
ILE A  52
 None
 1.31A 3frqA-2lyiA:
undetectable		 3frqA-2lyiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2lyi PROTEIN (ENTITY)
(Nephila
antipodiana) 		5 / 12 VAL A  68
ALA A  63
ILE A  91
LEU A 110
ILE A  84
 None
 1.14A 3qfxA-2lyiA:
undetectable		 3qfxA-2lyiA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2lyi PROTEIN (ENTITY)
(Nephila
antipodiana) 		5 / 12 VAL A  68
ALA A  63
ILE A  91
LEU A 110
ILE A  84
 None
 1.12A 3qfxB-2lyiA:
undetectable		 3qfxB-2lyiA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2lyi PROTEIN (ENTITY)
(Nephila
antipodiana) 		4 / 8 ALA A  13
THR A  17
THR A  19
ALA A  27
 None
 0.87A 5x2tI-2lyiA:
4.1
5x2tJ-2lyiA:
3.7
5x2tK-2lyiA:
4.3
5x2tL-2lyiA:
3.8		 5x2tI-2lyiA:
24.44
5x2tJ-2lyiA:
24.57
5x2tK-2lyiA:
24.44
5x2tL-2lyiA:
24.57