SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2m0m MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 4 THR A  52
LEU A  55
LEU A  62
GLN A  65
 None
 1.04A 1fbmA-2m0mA:
undetectable		 1fbmA-2m0mA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2m0m MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 4 THR A  52
LEU A  55
VAL A  58
LEU A  62
 None
 0.88A 1fbmD-2m0mA:
undetectable		 1fbmD-2m0mA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2m0m MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		5 / 5 THR A  52
LEU A  55
VAL A  58
LEU A  62
GLN A  65
 None
 1.22A 1fbmE-2m0mA:
undetectable		 1fbmE-2m0mA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 2m0m MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 7 VAL A  82
THR A  24
LEU A  28
VAL A  87
 None
 0.99A 1jgsA-2m0mA:
undetectable		 1jgsA-2m0mA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2m0m MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 7 PHE A  63
GLU A  77
SER A  76
VAL A  73
 None
 1.41A 3dqtA-2m0mA:
undetectable
3dqtB-2m0mA:
undetectable		 3dqtA-2m0mA:
16.49
3dqtB-2m0mA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2m0m MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 5 GLU A  85
SER A  89
ARG A  36
SER A  88
 None
 1.42A 4k17B-2m0mA:
undetectable		 4k17B-2m0mA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2m0m MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 7 PHE A  63
GLU A  77
SER A  76
VAL A  73
 None
 1.38A 5adlA-2m0mA:
undetectable
5adlB-2m0mA:
2.0		 5adlA-2m0mA:
16.49
5adlB-2m0mA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2m0m MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 7 SER A  76
VAL A  73
PHE A  63
GLU A  77
 None
 1.42A 6av6A-2m0mA:
undetectable
6av6B-2m0mA:
undetectable		 6av6A-2m0mA:
19.83
6av6B-2m0mA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2m0m MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 7 PHE A  63
GLU A  77
SER A  76
VAL A  73
 None
 1.43A 6av6C-2m0mA:
undetectable
6av6D-2m0mA:
undetectable		 6av6C-2m0mA:
19.83
6av6D-2m0mA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2m0m MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 7 SER A  76
VAL A  73
PHE A  63
GLU A  77
 None
 1.41A 6av7A-2m0mA:
undetectable
6av7B-2m0mA:
undetectable		 6av7A-2m0mA:
19.83
6av7B-2m0mA:
19.83