SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 2m1w TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 4 ASP A  89
LEU A 139
LEU A 180
LEU A 138
 None
 1.29A 1u18A-2m1wA:
undetectable		 1u18A-2m1wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2m1w TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 2
(Homo
sapiens) 		3 / 3 ILE A  83
ASP A  89
PHE A 143
 None
 0.53A 1uwjB-2m1wA:
undetectable		 1uwjB-2m1wA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2m1w TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 7 GLU A  92
PHE A  81
ILE A 136
PHE A 210
 None
 0.92A 2qmzA-2m1wA:
3.6
2qmzB-2m1wA:
4.1		 2qmzA-2m1wA:
25.91
2qmzB-2m1wA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 2m1w TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 2
(Homo
sapiens) 		5 / 12 ILE A 136
LEU A  99
GLU A 197
PHE A 202
GLN A 205
 None
 1.19A 2w3mB-2m1wA:
undetectable		 2w3mB-2m1wA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2m1w TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 6 ALA A 133
GLN A 218
VAL A 214
TYR A 215
 None
 1.07A 5i8fA-2m1wA:
undetectable		 5i8fA-2m1wA:
22.65