SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2m2a FKBP-TYPE 16 KDA
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		3 / 3 ILE A 121
ASP A 124
PHE A 125
 None
 0.62A 1uwjB-2m2aA:
undetectable		 1uwjB-2m2aA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2m2a FKBP-TYPE 16 KDA
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		4 / 5 GLN A  80
PHE A  82
PHE A  87
GLY A 111
 None
 1.36A 2qmzA-2m2aA:
undetectable
2qmzB-2m2aA:
undetectable		 2qmzA-2m2aA:
25.13
2qmzB-2m2aA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2m2a FKBP-TYPE 16 KDA
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		4 / 7 GLU A  26
PHE A  15
ALA A  70
GLY A  72
 None
 0.93A 5uxdA-2m2aA:
undetectable		 5uxdA-2m2aA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2m2a FKBP-TYPE 16 KDA
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		4 / 6 GLY A 118
ASP A 119
SER A  83
ARG A  85
 None
 1.10A 6dwdA-2m2aA:
undetectable
6dwdC-2m2aA:
undetectable		 6dwdA-2m2aA:
14.50
6dwdC-2m2aA:
14.50