SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YFB_C_PACC601_0 (PROTEIN RELATED TO PENICILLIN ACYLASE)	2m3t	BETA-CRYSTALLIN S (Homo sapiens)	5 / 12	TRP A 137 PHE A 139 PHE A 173 ILE A 127 VAL A 132	None	1.28A	4yfbC-2m3tA: 0.0	4yfbC-2m3tA: 14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YFB_F_PACF601_0 (PROTEIN RELATED TO PENICILLIN ACYLASE)	2m3t	BETA-CRYSTALLIN S (Homo sapiens)	5 / 12	TRP A 137 PHE A 139 PHE A 173 ILE A 127 VAL A 132	None	1.28A	4yfbF-2m3tA: 0.0	4yfbF-2m3tA: 14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YFB_I_PACI601_0 (PROTEIN RELATED TO PENICILLIN ACYLASE)	2m3t	BETA-CRYSTALLIN S (Homo sapiens)	5 / 12	TRP A 137 PHE A 139 PHE A 173 ILE A 127 VAL A 132	None	1.26A	4yfbI-2m3tA: undetectable	4yfbI-2m3tA: 14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YFB_L_PACL601_0 (PROTEIN RELATED TO PENICILLIN ACYLASE)	2m3t	BETA-CRYSTALLIN S (Homo sapiens)	5 / 12	TRP A 137 PHE A 139 PHE A 173 ILE A 127 VAL A 132	None	1.27A	4yfbL-2m3tA: undetectable	4yfbL-2m3tA: 14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HQA_A_ACRA705_2 (ALPHA-GLUCOSIDASE)	2m3t	BETA-CRYSTALLIN S (Homo sapiens)	4 / 8	PHE A 99 GLU A 100 HIS A 123 THR A 112	None	1.43A	5hqaA-2m3tA: undetectable	5hqaA-2m3tA: 13.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4YFB_C_PACC601_0","PROTEIN RELATED TO PENICILLIN ACYLASE","2m3t","BETA-CRYSTALLIN S","Homo sapiens",5,"TRP A 137;PHE A 139;PHE A 173;ILE A 127;VAL A 132","None","1.28A","4yfbC-2m3tA:0.0","4yfbC-2m3tA:14.78"],["4YFB_F_PACF601_0","PROTEIN RELATED TO PENICILLIN ACYLASE","2m3t","BETA-CRYSTALLIN S","Homo sapiens",5,"TRP A 137;PHE A 139;PHE A 173;ILE A 127;VAL A 132","None","1.28A","4yfbF-2m3tA:0.0","4yfbF-2m3tA:14.78"],["4YFB_I_PACI601_0","PROTEIN RELATED TO PENICILLIN ACYLASE","2m3t","BETA-CRYSTALLIN S","Homo sapiens",5,"TRP A 137;PHE A 139;PHE A 173;ILE A 127;VAL A 132","None","1.26A","4yfbI-2m3tA:undetectable","4yfbI-2m3tA:14.78"],["4YFB_L_PACL601_0","PROTEIN RELATED TO PENICILLIN ACYLASE","2m3t","BETA-CRYSTALLIN S","Homo sapiens",5,"TRP A 137;PHE A 139;PHE A 173;ILE A 127;VAL A 132","None","1.27A","4yfbL-2m3tA:undetectable","4yfbL-2m3tA:14.78"],["5HQA_A_ACRA705_2","ALPHA-GLUCOSIDASE","2m3t","BETA-CRYSTALLIN S","Homo sapiens",4,"PHE A  99;GLU A 100;HIS A 123;THR A 112","None","1.43A","5hqaA-2m3tA:undetectable","5hqaA-2m3tA:13.27"]]