SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2m48 E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Drosophila
melanogaster) 		4 / 8 THR A 372
GLY A 378
GLY A 388
PHE A 381
 None
 0.73A 1d0vA-2m48A:
undetectable		 1d0vA-2m48A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2m48 E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Drosophila
melanogaster) 		4 / 8 THR A 372
GLY A 378
GLY A 388
PHE A 381
 None
 0.75A 1jhaA-2m48A:
undetectable		 1jhaA-2m48A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2m48 E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Drosophila
melanogaster) 		4 / 8 THR A 372
GLY A 378
GLY A 388
PHE A 381
 None
 0.73A 1jhqA-2m48A:
undetectable		 1jhqA-2m48A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2m48 E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Drosophila
melanogaster) 		4 / 8 THR A 372
GLY A 378
GLY A 388
PHE A 381
 None
 0.76A 1jhvA-2m48A:
undetectable		 1jhvA-2m48A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 2m48 E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Drosophila
melanogaster) 		3 / 3 GLY A 388
CYH A 385
CYH A 382
 None
ZN  A 502 (-2.1A)
ZN  A 502 (-2.1A)
 0.95A 5inzB-2m48A:
undetectable		 5inzB-2m48A:
14.02