SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2m4l PROTEIN BT_0846
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE A  51
TYR A  53
VAL A  86
PHE A  29
 None
 0.88A 3ltwA-2m4lA:
undetectable		 3ltwA-2m4lA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2m4l PROTEIN BT_0846
(Bacteroides
thetaiotaomicron) 		5 / 8 ILE A  55
ILE A  12
PHE A  29
VAL A  86
SER A  90
 None
 1.21A 4ac9C-2m4lA:
undetectable		 4ac9C-2m4lA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2m4l PROTEIN BT_0846
(Bacteroides
thetaiotaomicron) 		5 / 8 ILE A  55
ILE A  12
PHE A  29
VAL A  86
SER A  90
 None
 1.20A 4acbC-2m4lA:
undetectable		 4acbC-2m4lA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2m4l PROTEIN BT_0846
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  14
SER A  28
ILE A  79
GLY A  81
ASN A  10
 None
 1.05A 4obwA-2m4lA:
undetectable		 4obwA-2m4lA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2m4l PROTEIN BT_0846
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  14
SER A  28
ILE A  79
GLY A  81
ASN A  10
 None
 1.04A 4obwC-2m4lA:
undetectable		 4obwC-2m4lA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2m4l PROTEIN BT_0846
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A   7
ILE A  13
GLY A  35
ILE A  55
ILE A  12
 None
 0.88A 5e5jB-2m4lA:
undetectable		 5e5jB-2m4lA:
20.37