SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2m4n PROTEIN AFD-1,
ISOFORM A
(Caenorhabditis
elegans) 		3 / 3 LEU A   7
GLU A  26
ILE A  27
 None
 0.60A 3czhA-2m4nA:
undetectable		 3czhA-2m4nA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2m4n PROTEIN AFD-1,
ISOFORM A
(Caenorhabditis
elegans) 		4 / 7 PHE A 100
VAL A  56
VAL A  54
LEU A  53
 None
 0.89A 3hs6B-2m4nA:
undetectable		 3hs6B-2m4nA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2m4n PROTEIN AFD-1,
ISOFORM A
(Caenorhabditis
elegans) 		4 / 8 ARG A  33
LEU A   7
ALA A  38
ALA A  37
 None
 0.98A 3ns1L-2m4nA:
undetectable		 3ns1L-2m4nA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2m4n PROTEIN AFD-1,
ISOFORM A
(Caenorhabditis
elegans) 		3 / 3 LYS A   1
LEU A   7
ILE A  27
 None
 0.69A 5kc0A-2m4nA:
undetectable		 5kc0A-2m4nA:
18.95