SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		3 / 3 ASP A 131
ARG A 133
ASP A  75
 None
 0.93A 1vptA-2m5tA:
undetectable		 1vptA-2m5tA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		4 / 7 ALA A  30
ALA A  33
THR A 120
LEU A  93
 None
 0.92A 2wx2A-2m5tA:
undetectable		 2wx2A-2m5tA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		4 / 8 ALA A  30
ALA A  33
THR A 120
LEU A  93
 None
 1.00A 2wx2B-2m5tA:
undetectable		 2wx2B-2m5tA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		4 / 8 ALA A  30
ALA A  33
THR A 120
LEU A  93
 None
 0.88A 3khmA-2m5tA:
undetectable		 3khmA-2m5tA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		4 / 8 ALA A  30
ALA A  33
THR A 120
LEU A  93
 None
 0.83A 3l4dA-2m5tA:
undetectable		 3l4dA-2m5tA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		4 / 8 ALA A  30
ALA A  33
THR A 120
LEU A  93
 None
 0.89A 3l4dD-2m5tA:
undetectable		 3l4dD-2m5tA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		4 / 7 TYR A 135
ASP A  38
ALA A  12
TYR A  14
 None
 1.06A 3rodD-2m5tA:
undetectable		 3rodD-2m5tA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		3 / 3 ASP A 131
ARG A 133
ASP A  75
 None
 0.60A 4fp9D-2m5tA:
undetectable		 4fp9D-2m5tA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		3 / 3 ASP A 131
ARG A 133
ASP A  75
 None
 0.65A 4fzvA-2m5tA:
undetectable		 4fzvA-2m5tA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		4 / 5 SER A  60
ARG A  65
LEU A  63
ASP A  64
 None
 1.12A 4ifxA-2m5tA:
undetectable		 4ifxA-2m5tA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		4 / 5 SER A  60
ARG A  65
LEU A  63
ASP A  64
 None
 1.10A 4ig1A-2m5tA:
undetectable		 4ig1A-2m5tA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		4 / 7 GLY A 122
GLY A 125
TYR A  58
ALA A 128
 None
 0.93A 5e26A-2m5tA:
undetectable
5e26B-2m5tA:
undetectable		 5e26A-2m5tA:
17.51
5e26B-2m5tA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		3 / 3 ASP A 131
ARG A 133
ASP A  75
 None
 0.74A 5zvgA-2m5tA:
undetectable		 5zvgA-2m5tA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		3 / 3 ASP A 131
ARG A 133
ASP A  75
 None
 0.71A 5zvgB-2m5tA:
undetectable		 5zvgB-2m5tA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		5 / 12 ILE A 119
ASN A  16
LEU A  35
GLY A 117
PHE A 129
 None
 1.15A 6r2eA-2m5tA:
undetectable		 6r2eA-2m5tA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2m5t HUMAN RHINOVIRUS 2A
PROTEINASE
(Rhinovirus
C) 		5 / 12 ILE A 119
ASN A  16
LEU A  35
GLY A 117
PHE A 129
 None
 1.19A 6r2eE-2m5tA:
undetectable		 6r2eE-2m5tA:
18.49