SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DM6_A_IMNA1401_1 (NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGEN ASE)	2m6b	FULL-LENGTH TRANSMEMBRANE DOMAINS OF HUMAN GLYCINE RECEPTOR ALPHA1 SUBUNIT (Homo sapiens)	5 / 10	ILE A 285 ALA A 282 ILE A 225 ILE A 417 TYR A 228	None	1.16A	2dm6A-2m6bA: undetectable 2dm6B-2m6bA: undetectable	2dm6A-2m6bA: 18.36 2dm6B-2m6bA: 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V1F_B_BQ1B1087_0 (F0F1 ATP SYNTHASE SUBUNIT C)	2m6b	FULL-LENGTH TRANSMEMBRANE DOMAINS OF HUMAN GLYCINE RECEPTOR ALPHA1 SUBUNIT (Homo sapiens)	5 / 8	ALA A 406 ILE A 409 ALA A 297 PHE A 295 LEU A 292	None	1.38A	4v1fA-2m6bA: undetectable 4v1fB-2m6bA: undetectable	4v1fA-2m6bA: 20.13 4v1fB-2m6bA: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A94_A_ZOTA3001_0 (5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562)	2m6b	FULL-LENGTH TRANSMEMBRANE DOMAINS OF HUMAN GLYCINE RECEPTOR ALPHA1 SUBUNIT (Homo sapiens)	5 / 12	LEU A 261 VAL A 260 GLY A 256 PHE A 293 VAL A 294	None	1.41A	6a94A-2m6bA: 2.8	6a94A-2m6bA: 18.80

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2DM6_A_IMNA1401_1","NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE;NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE","2m6b","FULL-LENGTH TRANSMEMBRANE DOMAINS OF HUMAN GLYCINE RECEPTOR ALPHA1 SUBUNIT","Homo sapiens",5,"ILE A 285;ALA A 282;ILE A 225;ILE A 417;TYR A 228","None","1.16A","2dm6A-2m6bA:undetectable;2dm6B-2m6bA:undetectable","2dm6A-2m6bA:18.36;2dm6B-2m6bA:18.36"],["4V1F_B_BQ1B1087_0","F0F1 ATP SYNTHASE SUBUNIT C","2m6b","FULL-LENGTH TRANSMEMBRANE DOMAINS OF HUMAN GLYCINE RECEPTOR ALPHA1 SUBUNIT","Homo sapiens",5,"ALA A 406;ILE A 409;ALA A 297;PHE A 295;LEU A 292","None","1.38A","4v1fA-2m6bA:undetectable;4v1fB-2m6bA:undetectable","4v1fA-2m6bA:20.13;4v1fB-2m6bA:20.13"],["6A94_A_ZOTA3001_0","5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562","2m6b","FULL-LENGTH TRANSMEMBRANE DOMAINS OF HUMAN GLYCINE RECEPTOR ALPHA1 SUBUNIT","Homo sapiens",5,"LEU A 261;VAL A 260;GLY A 256;PHE A 293;VAL A 294","None","1.41A","6a94A-2m6bA:2.8","6a94A-2m6bA:18.80"]]