SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 2m7s SERINE/ARGININE-RICH
SPLICING FACTOR 1
(Homo
sapiens) 		5 / 12 VAL A  47
LEU A  70
THR A  73
PRO A  24
GLY A  22
 None
 1.29A 1ia0B-2m7sA:
undetectable		 1ia0B-2m7sA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 2m7s SERINE/ARGININE-RICH
SPLICING FACTOR 1
(Homo
sapiens) 		5 / 12 VAL A  47
LEU A  70
THR A  73
PRO A  24
GLY A  22
 None
 1.30A 1tubB-2m7sA:
undetectable		 1tubB-2m7sA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2m7s SERINE/ARGININE-RICH
SPLICING FACTOR 1
(Homo
sapiens) 		3 / 3 VAL A  47
VAL A  55
TRP A  29
 None
 0.85A 1w5uA-2m7sA:
undetectable
1w5uB-2m7sA:
undetectable		 1w5uA-2m7sA:
8.89
1w5uB-2m7sA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2m7s SERINE/ARGININE-RICH
SPLICING FACTOR 1
(Homo
sapiens) 		3 / 3 VAL A  55
TRP A  29
VAL A  47
 None
 0.79A 2izqC-2m7sA:
undetectable
2izqD-2m7sA:
undetectable		 2izqC-2m7sA:
8.89
2izqD-2m7sA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 2m7s SERINE/ARGININE-RICH
SPLICING FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A   8
GLY A  53
THR A  52
PHE A  75
ASP A  46
 None
 0.75A 3eluA-2m7sA:
undetectable		 3eluA-2m7sA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 2m7s SERINE/ARGININE-RICH
SPLICING FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A   8
GLY A  53
THR A  52
PHE A  75
ASP A  46
 None
 0.80A 3elwA-2m7sA:
undetectable		 3elwA-2m7sA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2m7s SERINE/ARGININE-RICH
SPLICING FACTOR 1
(Homo
sapiens) 		3 / 3 GLN A  30
TRP A  29
VAL A  47
 None
 0.81A 6auuA-2m7sA:
undetectable		 6auuA-2m7sA:
13.24