SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2m85 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH
(Homo
sapiens) 		3 / 3 HIS A 685
ILE A 662
LEU A 682
 ZN  A 801 (-3.1A)
None
ZN  A 802 ( 4.8A)
 0.76A 2kceA-2m85A:
undetectable		 2kceA-2m85A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2m85 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH
(Homo
sapiens) 		4 / 6 VAL A 689
CYH A 703
CYH A 677
HIS A 685
 None
ZN  A 802 (-2.3A)
ZN  A 802 (-2.3A)
ZN  A 801 (-3.1A)
 1.42A 5hrqH-2m85A:
undetectable
5hrqK-2m85A:
undetectable
5hrqL-2m85A:
undetectable		 5hrqH-2m85A:
16.67
5hrqK-2m85A:
19.67
5hrqL-2m85A:
16.67