SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m86'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2m86 E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		3 / 3 LYS B  96
PRO B  97
LEU B  98
 None
 0.48A 3tpxE-2m86B:
13.1		 3tpxE-2m86B:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2m86 E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 8 LEU B 119
LEU B 122
GLY B 123
VAL B 140
 None
 0.88A 4c9nA-2m86B:
undetectable		 4c9nA-2m86B:
14.67