SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2m8e SLEEPING BEAUTY
TRANSPOSASE
(synthetic
construct) 		3 / 3 SER A  26
SER A  25
HIS A  21
 None
 0.63A 3mzeA-2m8eA:
undetectable		 3mzeA-2m8eA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2m8e SLEEPING BEAUTY
TRANSPOSASE
(synthetic
construct) 		5 / 8 ASP A  19
VAL A  18
GLY A  24
VAL A  41
ILE A  17
 None
 1.30A 4ll3A-2m8eA:
undetectable		 4ll3A-2m8eA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 2m8e SLEEPING BEAUTY
TRANSPOSASE
(synthetic
construct) 		3 / 3 HIS A  50
HIS A  51
HIS A  56
 None
 0.95A 5oexA-2m8eA:
undetectable		 5oexA-2m8eA:
9.09