SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2m9p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
(Dengue
virus) 		4 / 6 GLU A  21
ILE A 200
TYR A 211
GLY A 197
 None
 0.86A 1maaB-2m9pA:
undetectable
1maaD-2m9pA:
undetectable		 1maaB-2m9pA:
16.97
1maaD-2m9pA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
(Dengue
virus) 		3 / 3 LEU A   8
LEU A 161
PHE A 107
 None
 0.68A 2pgrA-2m9pA:
undetectable		 2pgrA-2m9pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
(Dengue
virus) 		3 / 3 GLY A 212
TYR A 211
SER A 196
 None
 0.58A 2xatA-2m9pA:
undetectable		 2xatA-2m9pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
(Dengue
virus) 		5 / 11 GLY A  24
ARG A 168
ALA A 160
GLU A 162
ALA A 221
 None
 1.08A 3g88A-2m9pA:
undetectable		 3g88A-2m9pA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
(Dengue
virus) 		5 / 12 GLY A  24
ARG A 168
ALA A 160
GLU A 162
ALA A 221
 None
 1.09A 3g8bA-2m9pA:
undetectable		 3g8bA-2m9pA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
(Dengue
virus) 		3 / 3 GLU A 162
GLY A 194
THR A 195
 None
 0.53A 3iazA-2m9pA:
undetectable		 3iazA-2m9pA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
(Dengue
virus) 		5 / 12 LEU A 210
TYR A 222
GLY A 194
GLY A 197
SER A 196
 None
 1.04A 3ou7A-2m9pA:
undetectable		 3ou7A-2m9pA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
(Dengue
virus) 		5 / 12 LEU A 210
TYR A 222
GLY A 194
GLY A 197
SER A 196
 None
 1.06A 3ou7B-2m9pA:
undetectable		 3ou7B-2m9pA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
(Dengue
virus) 		5 / 12 LEU A 210
TYR A 222
GLY A 194
GLY A 197
SER A 196
 None
 0.99A 3ou7D-2m9pA:
undetectable		 3ou7D-2m9pA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
(Dengue
virus) 		4 / 5 GLY A  93
LEU A  92
SER A   2
GLN A  88
 None
 1.01A 6ji6A-2m9pA:
undetectable		 6ji6A-2m9pA:
20.93