SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 9 LEU A 112
LEU A 108
ILE A  33
THR A 122
ILE A   5
 None
 1.45A 1hzeA-2masA:
undetectable
1hzeB-2masA:
undetectable		 1hzeA-2masA:
16.29
1hzeB-2masA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 9 LEU A 112
LEU A 108
THR A  34
THR A 122
ILE A   5
 None
 1.46A 1hzeA-2masA:
undetectable
1hzeB-2masA:
undetectable		 1hzeA-2masA:
16.29
1hzeB-2masA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 9 THR A 122
ILE A   5
LEU A 112
LEU A 108
ILE A  33
 None
 1.45A 1hzeA-2masA:
undetectable
1hzeB-2masA:
undetectable		 1hzeA-2masA:
16.29
1hzeB-2masA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 9 THR A 122
ILE A   5
LEU A 112
LEU A 108
THR A  34
 None
 1.46A 1hzeA-2masA:
undetectable
1hzeB-2masA:
undetectable		 1hzeA-2masA:
16.29
1hzeB-2masA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 12 ALA A 105
VAL A  36
GLY A  66
ALA A 175
ILE A 169
 None
 1.15A 1kxhA-2masA:
undetectable		 1kxhA-2masA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		4 / 7 LEU A  42
VAL A  45
THR A  46
ASP A   8
 None
 0.76A 2qblA-2masA:
undetectable		 2qblA-2masA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		4 / 7 MET A 235
TYR A 229
ALA A 199
ALA A 197
 None
 0.91A 2wx2A-2masA:
undetectable		 2wx2A-2masA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		4 / 8 LYS A  99
ASP A  54
GLN A  50
GLU A  95
 None
 1.44A 3dh0A-2masA:
5.1		 3dh0A-2masA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		6 / 12 GLY A 155
GLY A 153
PHE A 167
VAL A 291
ALA A 165
THR A 275
 None
None
PIR  A 400 ( 4.0A)
None
None
None
 1.26A 3dh0B-2masA:
4.7		 3dh0B-2masA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 12 ASP A 242
PRO A  11
ILE A 169
MET A 152
ASP A  10
 PIR  A 400 (-2.5A)
None
None
PIR  A 400 (-3.5A)
CA  A 316 ( 3.1A)
 1.45A 3topA-2masA:
undetectable		 3topA-2masA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 8 GLY A 190
GLY A 154
MET A 152
LEU A 129
VAL A 186
 None
None
PIR  A 400 (-3.5A)
None
None
 1.27A 3v1nA-2masA:
4.0		 3v1nA-2masA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		4 / 5 PRO A  11
ASP A  15
ILE A  33
VAL A 246
 None
CA  A 316 (-2.2A)
None
None
 1.32A 4hytA-2masA:
5.0		 4hytA-2masA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		3 / 3 ASP A 296
LEU A 295
PHE A 297
 None
 0.68A 4pthA-2masA:
undetectable		 4pthA-2masA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 11 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.04A 4qvlK-2masA:
undetectable
4qvlL-2masA:
undetectable		 4qvlK-2masA:
22.08
4qvlL-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 9 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.03A 4qvmK-2masA:
undetectable
4qvmL-2masA:
undetectable		 4qvmK-2masA:
22.08
4qvmL-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 10 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.03A 4qvmY-2masA:
undetectable
4qvmZ-2masA:
undetectable		 4qvmY-2masA:
22.08
4qvmZ-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 10 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.02A 4qvpK-2masA:
undetectable
4qvpL-2masA:
undetectable		 4qvpK-2masA:
22.08
4qvpL-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 10 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.02A 4qvpY-2masA:
undetectable
4qvpZ-2masA:
undetectable		 4qvpY-2masA:
22.08
4qvpZ-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 11 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.02A 4qvwK-2masA:
undetectable
4qvwL-2masA:
undetectable		 4qvwK-2masA:
21.77
4qvwL-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 11 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.03A 4qvwY-2masA:
undetectable
4qvwZ-2masA:
undetectable		 4qvwY-2masA:
21.77
4qvwZ-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 11 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.02A 4qw1K-2masA:
undetectable
4qw1L-2masA:
undetectable		 4qw1K-2masA:
21.77
4qw1L-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 10 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.02A 4qw1Y-2masA:
undetectable
4qw1Z-2masA:
undetectable		 4qw1Y-2masA:
21.77
4qw1Z-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 10 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.05A 4qw3K-2masA:
undetectable
4qw3L-2masA:
undetectable		 4qw3K-2masA:
22.08
4qw3L-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 10 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.05A 4qw3Y-2masA:
undetectable
4qw3Z-2masA:
undetectable		 4qw3Y-2masA:
22.08
4qw3Z-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 9 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.20A 4qwuK-2masA:
undetectable
4qwuL-2masA:
undetectable		 4qwuK-2masA:
22.08
4qwuL-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 9 THR A 275
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.15A 4qwuY-2masA:
undetectable
4qwuZ-2masA:
undetectable		 4qwuY-2masA:
22.08
4qwuZ-2masA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 11 GLY A 302
LEU A 305
PHE A 297
LEU A 295
ALA A 197
 None
 0.96A 4wnuA-2masA:
undetectable		 4wnuA-2masA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 10 VAL A  36
LEU A 272
THR A 275
PRO A 125
LEU A 151
 None
 1.38A 5mm4B-2masA:
3.3		 5mm4B-2masA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 12 ILE A 132
ILE A   5
LEU A  30
VAL A  61
ILE A  33
 None
 1.08A 5mugA-2masA:
1.8		 5mugA-2masA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		3 / 3 LEU A  13
ILE A 221
TYR A  92
 None
 0.48A 5uunB-2masA:
undetectable		 5uunB-2masA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 10 GLY A 128
ASN A 131
ILE A 171
PRO A  70
GLY A  38
 None
 1.13A 6e5zA-2masA:
4.3		 6e5zA-2masA:
23.60