SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mbg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 6 LEU A 412
VAL A 372
VAL A 376
ILE A 207
 None
 0.96A 2hyyA-2mbgA:
undetectable		 2hyyA-2mbgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		3 / 3 VAL A 300
GLU A 366
GLU A 296
 None
 0.75A 2nv4A-2mbgA:
undetectable		 2nv4A-2mbgA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 4 ILE A 322
PHE A 360
ILE A 318
THR A 362
 None
 1.03A 3ia4A-2mbgA:
undetectable		 3ia4A-2mbgA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 6 LEU A 412
VAL A 372
VAL A 376
ILE A 207
 None
 1.06A 3k5vA-2mbgA:
undetectable		 3k5vA-2mbgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 6 LEU A 412
VAL A 372
VAL A 376
ILE A 207
 None
 1.00A 3k5vB-2mbgA:
undetectable		 3k5vB-2mbgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 8 LEU A 267
LEU A 278
ARG A 214
ILE A 217
PHE A 213
 None
 1.49A 3ln1A-2mbgA:
1.1		 3ln1A-2mbgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 7 LEU A 267
LEU A 278
ARG A 214
ILE A 217
PHE A 213
 None
 1.48A 3ln1B-2mbgA:
undetectable		 3ln1B-2mbgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		3 / 3 GLY A 229
ILE A 344
VAL A 345
 None
 0.38A 3nv6A-2mbgA:
undetectable		 3nv6A-2mbgA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 7 ILE A 342
LEU A 346
LEU A 271
VAL A 212
 None
 0.91A 3r9vA-2mbgA:
2.1
3r9vB-2mbgA:
2.9		 3r9vA-2mbgA:
22.54
3r9vB-2mbgA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 7 VAL A 350
LEU A 278
LEU A 279
ILE A 322
 None
 0.65A 3u5kB-2mbgA:
undetectable		 3u5kB-2mbgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 8 VAL A 350
LEU A 278
LEU A 279
ILE A 322
 None
 0.68A 3u5kC-2mbgA:
undetectable		 3u5kC-2mbgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 5 VAL A 350
LEU A 278
LEU A 279
ILE A 322
 None
 0.59A 4a9jA-2mbgA:
undetectable		 4a9jA-2mbgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 5 VAL A 350
LEU A 278
LEU A 279
ILE A 322
 None
 0.58A 4a9jB-2mbgA:
2.0		 4a9jB-2mbgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 5 VAL A 350
LEU A 278
LEU A 279
ILE A 322
 None
 0.64A 4a9jC-2mbgA:
undetectable		 4a9jC-2mbgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 8 VAL A 350
LEU A 278
LEU A 279
ILE A 322
 None
 0.78A 4lzrA-2mbgA:
undetectable		 4lzrA-2mbgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 10 PHE A 190
VAL A 212
LEU A 255
LEU A 243
THR A 253
 None
 1.29A 4zmeB-2mbgA:
undetectable		 4zmeB-2mbgA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 7 PRO A 260
VAL A 220
ILE A 217
PHE A 213
ILE A 230
 None
 1.48A 5bmvC-2mbgA:
undetectable		 5bmvC-2mbgA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 12 ILE A 217
PHE A 213
THR A 349
LEU A 317
TYR A 231
 None
 1.15A 5e8qB-2mbgA:
undetectable		 5e8qB-2mbgA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 9 GLN A 269
GLY A 191
ASN A 185
ILE A 189
ALA A 197
 None
 1.39A 5entC-2mbgA:
undetectable		 5entC-2mbgA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 8 HIS A 413
GLN A 417
LEU A 409
LEU A 429
 None
 1.06A 5hs6A-2mbgA:
undetectable		 5hs6A-2mbgA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 7 LEU A 373
GLU A 215
ILE A 230
VAL A 220
 None
 0.92A 5jh7C-2mbgA:
undetectable		 5jh7C-2mbgA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 6 GLU A 302
ARG A 305
LEU A 283
ARG A 286
 None
 1.23A 5l6eA-2mbgA:
undetectable
5l6eB-2mbgA:
undetectable		 5l6eA-2mbgA:
19.06
5l6eB-2mbgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 12 ILE A 217
PHE A 213
THR A 349
LEU A 317
TYR A 231
 None
 1.13A 5ujxB-2mbgA:
undetectable		 5ujxB-2mbgA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 8 LEU A 267
VAL A 220
LEU A 346
ILE A 230
 None
 0.85A 5v0vA-2mbgA:
2.3		 5v0vA-2mbgA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 8 VAL A 350
LEU A 278
LEU A 279
ILE A 322
 None
 0.77A 5y1yA-2mbgA:
undetectable		 5y1yA-2mbgA:
19.51