SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mbm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P6H_A_IBPA133_1 (FATTY ACID-BINDING PROTEIN, ADIPOCYTE)	2mbm	TOP7 FOLD PROTEIN TOP7M13 (synthetic construct)	4 / 7	ILE A 58 VAL A 10 ARG A 44 TYR A 23	None	1.10A	3p6hA-2mbmA: undetectable	3p6hA-2mbmA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_B_MXMB606_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2mbm	TOP7 FOLD PROTEIN TOP7M13 (synthetic construct)	5 / 12	VAL A 8 ILE A 80 VAL A 84 LEU A 88 LEU A 81	None	1.02A	4m11B-2mbmA: undetectable	4m11B-2mbmA: 10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_D_MXMD606_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2mbm	TOP7 FOLD PROTEIN TOP7M13 (synthetic construct)	5 / 12	VAL A 8 ILE A 80 VAL A 84 LEU A 88 LEU A 81	None	1.07A	4m11D-2mbmA: undetectable	4m11D-2mbmA: 10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4F_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	2mbm	TOP7 FOLD PROTEIN TOP7M13 (synthetic construct)	4 / 7	LEU A 25 TYR A 26 LEU A 33 GLU A 32	None	0.83A	4z4fA-2mbmA: undetectable	4z4fA-2mbmA: 10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T7B_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	2mbm	TOP7 FOLD PROTEIN TOP7M13 (synthetic construct)	4 / 7	LEU A 25 TYR A 26 LEU A 33 GLU A 32	None	0.79A	5t7bA-2mbmA: undetectable	5t7bA-2mbmA: 10.53

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3P6H_A_IBPA133_1","FATTY ACID-BINDING PROTEIN, ADIPOCYTE","2mbm","TOP7 FOLD PROTEIN TOP7M13","synthetic construct",4,"ILE A  58;VAL A  10;ARG A  44;TYR A  23","None","1.10A","3p6hA-2mbmA:undetectable","3p6hA-2mbmA:20.00"],["4M11_B_MXMB606_1","PROSTAGLANDIN G\/H SYNTHASE 2","2mbm","TOP7 FOLD PROTEIN TOP7M13","synthetic construct",5,"VAL A   8;ILE A  80;VAL A  84;LEU A  88;LEU A  81","None","1.02A","4m11B-2mbmA:undetectable","4m11B-2mbmA:10.95"],["4M11_D_MXMD606_1","PROSTAGLANDIN G\/H SYNTHASE 2","2mbm","TOP7 FOLD PROTEIN TOP7M13","synthetic construct",5,"VAL A   8;ILE A  80;VAL A  84;LEU A  88;LEU A  81","None","1.07A","4m11D-2mbmA:undetectable","4m11D-2mbmA:10.95"],["4Z4F_A_IPHA902_0","PROTEIN ARGONAUTE-2","2mbm","TOP7 FOLD PROTEIN TOP7M13","synthetic construct",4,"LEU A  25;TYR A  26;LEU A  33;GLU A  32","None","0.83A","4z4fA-2mbmA:undetectable","4z4fA-2mbmA:10.53"],["5T7B_A_IPHA902_0","PROTEIN ARGONAUTE-2","2mbm","TOP7 FOLD PROTEIN TOP7M13","synthetic construct",4,"LEU A  25;TYR A  26;LEU A  33;GLU A  32","None","0.79A","5t7bA-2mbmA:undetectable","5t7bA-2mbmA:10.53"]]