SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		3 / 3 SER A 229
GLY A 228
ARG A 214
 EPU  A 402 (-3.0A)
EPU  A 402 ( 3.5A)
FAD  A 401 ( 2.8A)
 0.65A 1t9wA-2mbrA:
2.1		 1t9wA-2mbrA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		3 / 3 ARG A 159
SER A 229
TYR A 158
 FAD  A 401 ( 3.2A)
EPU  A 402 (-3.0A)
EPU  A 402 (-4.2A)
 0.99A 2q2hA-2mbrA:
undetectable
2q2hB-2mbrA:
undetectable		 2q2hA-2mbrA:
17.65
2q2hB-2mbrA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		3 / 3 ASN A 226
ASP A 220
ARG A  66
 FAD  A 401 (-3.5A)
None
None
 0.83A 3k13A-2mbrA:
undetectable		 3k13A-2mbrA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 6 PRO A 221
GLY A 225
ASN A 294
ASN A   9
 FAD  A 401 ( 4.9A)
None
None
None
 1.02A 3zqtA-2mbrA:
undetectable		 3zqtA-2mbrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 5 VAL A  52
ARG A 327
GLU A 334
LEU A  44
 FAD  A 401 (-4.1A)
FAD  A 401 (-3.2A)
None
FAD  A 401 (-4.5A)
 0.83A 4hojA-2mbrA:
undetectable		 4hojA-2mbrA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		5 / 12 TYR A 190
GLN A 288
ALA A 264
GLN A 256
GLY A 123
 EPU  A 402 (-4.1A)
EPU  A 402 (-3.1A)
EPU  A 402 (-3.4A)
None
FAD  A 401 (-4.1A)
 1.12A 4iilA-2mbrA:
undetectable		 4iilA-2mbrA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		5 / 8 LEU A 107
LEU A 104
LEU A 180
ILE A 122
VAL A 176
 None
None
None
FAD  A 401 (-4.0A)
None
 1.49A 4klaA-2mbrA:
undetectable		 4klaA-2mbrA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		3 / 3 VAL A 236
SER A 237
THR A 240
 None
 0.45A 4luhA-2mbrA:
undetectable		 4luhA-2mbrA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 5 ILE A 162
ASP A 169
GLU A 166
VAL A 147
 None
 0.82A 4nkxC-2mbrA:
undetectable		 4nkxC-2mbrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 6 LYS A 217
LEU A 218
ASN A 226
PRO A 219
 EPU  A 402 (-3.6A)
EPU  A 402 ( 4.6A)
FAD  A 401 (-3.5A)
None
 1.37A 4yv5B-2mbrA:
undetectable		 4yv5B-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 6 PHE A 318
LEU A 322
ASN A 233
PRO A 234
 None
None
EPU  A 402 (-2.9A)
None
 1.30A 4yv5B-2mbrA:
undetectable		 4yv5B-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 6 LYS A 217
LEU A 218
ASN A 226
PRO A 219
 EPU  A 402 (-3.6A)
EPU  A 402 ( 4.6A)
FAD  A 401 (-3.5A)
None
 1.40A 4yv5A-2mbrA:
undetectable		 4yv5A-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 6 PHE A 318
LEU A 322
ASN A 233
PRO A 234
 None
None
EPU  A 402 (-2.9A)
None
 1.31A 4yv5A-2mbrA:
undetectable		 4yv5A-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 173
ALA A  85
LEU A  29
ASN A  65
PHE A 163
 FAD  A 401 (-4.1A)
FAD  A 401 ( 4.2A)
None
FAD  A 401 (-3.9A)
None
 1.49A 4zo1X-2mbrA:
undetectable		 4zo1X-2mbrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		5 / 9 ILE A  64
ILE A  45
ILE A  67
ALA A  23
LEU A  29
 None
FAD  A 401 (-4.3A)
None
None
None
 1.12A 5mvmA-2mbrA:
undetectable
5mvmE-2mbrA:
undetectable		 5mvmA-2mbrA:
13.85
5mvmE-2mbrA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 7 ARG A  66
LEU A  44
VAL A  62
TRP A   8
 None
FAD  A 401 (-4.5A)
None
None
 0.89A 6g2pA-2mbrA:
undetectable		 6g2pA-2mbrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 7 LEU A 129
VAL A  83
LEU A 178
LEU A 180
 None
 0.75A 6g9bA-2mbrA:
undetectable
6g9bB-2mbrA:
undetectable		 6g9bA-2mbrA:
15.46
6g9bB-2mbrA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 7 GLY A 333
HIS A  19
GLU A  39
GLY A  40
 None
 0.93A 6n7fA-2mbrA:
undetectable		 6n7fA-2mbrA:
14.33