SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)		 2mc3 MUS81 ENDONUCLEASE
HOMOLOG (YEAST),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 9 LEU A  89
ALA A  90
LEU A  97
HIS A  22
LEU A  23
 None
 1.37A 1gwrB-2mc3A:
undetectable		 1gwrB-2mc3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 2mc3 MUS81 ENDONUCLEASE
HOMOLOG (YEAST),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 10 ALA A  90
GLU A  93
LEU A  97
HIS A  22
LEU A  23
 None
 1.23A 2ocfA-2mc3A:
undetectable		 2ocfA-2mc3A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2mc3 MUS81 ENDONUCLEASE
HOMOLOG (YEAST),
ISOFORM CRA_B
(Homo
sapiens) 		4 / 6 LEU A  18
TYR A  19
ARG A  39
LEU A  78
 None
 1.17A 3rd0A-2mc3A:
undetectable		 3rd0A-2mc3A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2mc3 MUS81 ENDONUCLEASE
HOMOLOG (YEAST),
ISOFORM CRA_B
(Homo
sapiens) 		4 / 6 ALA A  90
GLN A  87
LEU A  16
LEU A  23
 None
 1.20A 4xp3A-2mc3A:
undetectable		 4xp3A-2mc3A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2mc3 MUS81 ENDONUCLEASE
HOMOLOG (YEAST),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 11 LEU A  89
ALA A  90
LEU A  97
HIS A  22
LEU A  23
 None
 1.37A 5hyrB-2mc3A:
undetectable		 5hyrB-2mc3A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2mc3 MUS81 ENDONUCLEASE
HOMOLOG (YEAST),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 10 LEU A  89
ALA A  90
LEU A  97
HIS A  22
LEU A  23
 None
 1.36A 6cbzB-2mc3A:
undetectable		 6cbzB-2mc3A:
24.24