SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mdt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 2mdt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 9 ASN A  20
ILE A 102
PRO A 103
ALA A  85
ILE A  84
 None
 1.49A 1aj6A-2mdtA:
undetectable		 1aj6A-2mdtA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2mdt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		6 / 12 ILE A   5
ALA A  72
LYS A   1
ILE A 102
ILE A  84
THR A  28
 None
 1.49A 1rb3B-2mdtA:
undetectable		 1rb3B-2mdtA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2mdt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		6 / 12 ILE A   5
ALA A  72
LYS A   1
ILE A 102
ILE A  84
THR A  28
 None
 1.48A 1rx2A-2mdtA:
undetectable		 1rx2A-2mdtA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2mdt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A  97
ILE A   5
LEU A  13
ILE A  84
ILE A  40
 None
 1.06A 2ygnA-2mdtA:
undetectable		 2ygnA-2mdtA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 2mdt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 ILE A  40
LEU A  17
ILE A   5
SER A   6
ILE A  42
 None
 0.99A 3cd2A-2mdtA:
undetectable		 3cd2A-2mdtA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2mdt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		6 / 12 ALA A   9
GLY A  31
ALA A   3
ILE A  16
VAL A  50
VAL A  26
 None
 1.32A 4nkxB-2mdtA:
undetectable		 4nkxB-2mdtA:
14.37