SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mf2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2mf2 MRNA INTERFERASE
MAZF
(Staphylococcus
aureus) 		3 / 3 ILE A  54
ILE A  91
THR A  52
 None
 0.65A 1rg7A-2mf2A:
undetectable		 1rg7A-2mf2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 2mf2 MRNA INTERFERASE
MAZF
(Staphylococcus
aureus) 		5 / 12 ASP A 115
ASP A 108
ASP A 109
GLY A  17
ILE A  40
 None
 0.94A 2ieoA-2mf2A:
undetectable		 2ieoA-2mf2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 2mf2 MRNA INTERFERASE
MAZF
(Staphylococcus
aureus) 		6 / 12 LEU A 118
ASP A 115
ASP A 108
ASP A 109
GLY A  17
LEU A  88
 None
 1.31A 2o4nA-2mf2A:
undetectable		 2o4nA-2mf2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 2mf2 MRNA INTERFERASE
MAZF
(Staphylococcus
aureus) 		5 / 11 LEU A 118
ASP A 115
ASP A 108
GLY A  17
ILE A  40
 None
 1.05A 2o4pA-2mf2A:
undetectable		 2o4pA-2mf2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 2mf2 MRNA INTERFERASE
MAZF
(Staphylococcus
aureus) 		4 / 5 PRO A  26
ARG A  92
ARG A  98
ASP A  23
 None
 1.34A 2rhmB-2mf2A:
undetectable		 2rhmB-2mf2A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2mf2 MRNA INTERFERASE
MAZF
(Staphylococcus
aureus) 		5 / 12 ASP A 115
ASP A 108
ASP A 109
GLY A  17
ILE A  40
 None
 0.85A 3cywA-2mf2A:
undetectable		 3cywA-2mf2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 2mf2 MRNA INTERFERASE
MAZF
(Staphylococcus
aureus) 		5 / 12 ASP A 115
ASP A 108
ASP A 109
GLY A  17
ILE A  40
 None
 0.94A 3jvyA-2mf2A:
undetectable		 3jvyA-2mf2A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2mf2 MRNA INTERFERASE
MAZF
(Staphylococcus
aureus) 		6 / 12 LEU A 118
ASP A 115
ASP A 108
ASP A 109
GLY A  17
ILE A  40
 None
 1.28A 3lzuB-2mf2A:
undetectable		 3lzuB-2mf2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2mf2 MRNA INTERFERASE
MAZF
(Staphylococcus
aureus) 		3 / 3 LYS A  77
LYS A 110
SER A 107
 None
 1.24A 5odiA-2mf2A:
undetectable		 5odiA-2mf2A:
11.53