SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE
(Streptomyces
virginiae) 		4 / 7 PHE A6776
LEU A6766
ARG A6756
GLU A6741
 None
 1.02A 2jn3A-2mf4A:
undetectable		 2jn3A-2mf4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE
(Streptomyces
virginiae) 		5 / 10 LEU A6793
VAL A6777
SER A6809
ILE A6806
PHE A6802
 None
 1.14A 2w9hA-2mf4A:
undetectable		 2w9hA-2mf4A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE
(Streptomyces
virginiae) 		3 / 3 THR A6762
LYS A  -4
GLU A6761
 None
 0.99A 3ijdB-2mf4A:
undetectable		 3ijdB-2mf4A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE
(Streptomyces
virginiae) 		5 / 12 PHE A6763
LEU A6745
THR A6765
PHE A6776
ILE A6806
 None
 1.01A 3nxuB-2mf4A:
undetectable		 3nxuB-2mf4A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE
(Streptomyces
virginiae) 		4 / 8 PHE A6763
ALA A6803
LEU A6745
LEU A6746
 None
 0.85A 4ejgB-2mf4A:
undetectable		 4ejgB-2mf4A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE
(Streptomyces
virginiae) 		4 / 7 PHE A6763
ALA A6803
LEU A6745
LEU A6746
 None
 0.89A 4ejgC-2mf4A:
undetectable		 4ejgC-2mf4A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE
(Streptomyces
virginiae) 		4 / 8 PHE A6776
ALA A6792
LEU A6793
GLY A6773
 None
 0.90A 4xk8a-2mf4A:
undetectable		 4xk8a-2mf4A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE
(Streptomyces
virginiae) 		4 / 7 LEU A6750
TYR A6751
LEU A6772
GLU A6775
 None
 1.02A 4z4fA-2mf4A:
2.1		 4z4fA-2mf4A:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE
(Streptomyces
virginiae) 		4 / 7 LEU A6750
TYR A6751
LEU A6772
GLU A6775
 None
 1.02A 5t7bA-2mf4A:
undetectable		 5t7bA-2mf4A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE
(Streptomyces
virginiae) 		5 / 12 PHE A6802
ILE A6806
PHE A6763
ALA A6779
ALA A6747
 None
 1.22A 5vcgA-2mf4A:
undetectable		 5vcgA-2mf4A:
12.07