SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		4 / 8 ILE A 104
VAL A  23
MET A 100
LEU A  62
 None
 0.84A 1dzmA-2mfqA:
undetectable		 1dzmA-2mfqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		4 / 8 THR A  41
TYR A  59
LEU A  97
MET A  38
 None
 1.23A 1uw6A-2mfqA:
undetectable
1uw6B-2mfqA:
undetectable		 1uw6A-2mfqA:
17.07
1uw6B-2mfqA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		4 / 8 THR A  41
TYR A  59
LEU A  97
MET A  38
 None
 1.25A 1uw6D-2mfqA:
undetectable
1uw6E-2mfqA:
undetectable		 1uw6D-2mfqA:
17.07
1uw6E-2mfqA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		4 / 8 THR A  41
TYR A  59
LEU A  97
MET A  38
 None
 1.25A 1uw6G-2mfqA:
undetectable
1uw6H-2mfqA:
undetectable		 1uw6G-2mfqA:
17.07
1uw6H-2mfqA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		4 / 8 THR A  41
TYR A  59
LEU A  97
MET A  38
 None
 1.26A 1uw6P-2mfqA:
undetectable
1uw6Q-2mfqA:
undetectable		 1uw6P-2mfqA:
17.07
1uw6Q-2mfqA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		4 / 8 LEU A  97
MET A  38
THR A  41
TYR A  59
 None
 1.24A 1uw6P-2mfqA:
undetectable
1uw6T-2mfqA:
undetectable		 1uw6P-2mfqA:
17.07
1uw6T-2mfqA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens;
Homo
sapiens) 		4 / 5 LEU A  40
TYR A  59
GLN B 511
TYR A  65
 None
 1.44A 1yc2B-2mfqA:
0.0
1yc2C-2mfqA:
0.0		 1yc2B-2mfqA:
17.23
1yc2C-2mfqA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		5 / 12 ARG A  79
PHE A  74
GLY A  77
ILE A  86
PHE A  72
 None
None
PTR  B 512 ( 3.1A)
None
None
 1.48A 3a25A-2mfqA:
undetectable		 3a25A-2mfqA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		4 / 8 GLY A  83
PHE A  87
ILE A  46
MET A  38
 None
 0.92A 3ko0O-2mfqA:
undetectable
3ko0Q-2mfqA:
undetectable		 3ko0O-2mfqA:
20.97
3ko0Q-2mfqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		4 / 8 THR A  41
TYR A  59
LEU A  97
MET A  38
 None
 1.26A 3wipG-2mfqA:
undetectable
3wipH-2mfqA:
undetectable		 3wipG-2mfqA:
17.07
3wipH-2mfqA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		4 / 8 LEU A  97
MET A  38
THR A  41
TYR A  59
 None
 1.27A 3wipF-2mfqA:
undetectable
3wipJ-2mfqA:
undetectable		 3wipF-2mfqA:
17.07
3wipJ-2mfqA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		4 / 6 LYS A  20
PHE A  89
PHE A  72
LEU A 101
 None
 1.16A 5x19P-2mfqA:
undetectable		 5x19P-2mfqA:
15.08