SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2mgs C-X-C MOTIF
CHEMOKINE 5
(Homo
sapiens) 		5 / 12 LEU A  63
GLY A  21
GLN A  20
ALA A  46
LEU A  30
 None
 1.03A 1gs4A-2mgsA:
undetectable		 1gs4A-2mgsA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2mgs C-X-C MOTIF
CHEMOKINE 5
(Homo
sapiens) 		5 / 10 ALA A  46
ILE A  67
LEU A  30
ASP A  57
LEU A  63
 None
 1.13A 1yi4A-2mgsA:
undetectable		 1yi4A-2mgsA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 2mgs C-X-C MOTIF
CHEMOKINE 5
(Homo
sapiens) 		5 / 12 LEU A  63
GLY A  21
GLN A  20
ALA A  46
LEU A  30
 None
 1.06A 2oz7A-2mgsA:
undetectable		 2oz7A-2mgsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2mgs C-X-C MOTIF
CHEMOKINE 5
(Homo
sapiens) 		3 / 3 LEU A  48
MET A  26
ASP A  57
 None
 0.63A 4j7xB-2mgsA:
undetectable		 4j7xB-2mgsA:
15.50