SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 2mgv BIFUNCTIONAL
MEMBRANE-ASSOCIATED
PENICILLIN-BINDING
PROTEIN 1A/1B PONA2
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  57
THR A  58
ARG A  16
LYS A  20
 None
 1.26A 2kotA-2mgvA:
undetectable		 2kotA-2mgvA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2mgv BIFUNCTIONAL
MEMBRANE-ASSOCIATED
PENICILLIN-BINDING
PROTEIN 1A/1B PONA2
(Mycobacterium
tuberculosis) 		4 / 8 VAL A   7
SER A  32
VAL A  26
VAL A  12
 None
 1.26A 2y05A-2mgvA:
undetectable
2y05B-2mgvA:
undetectable		 2y05A-2mgvA:
13.46
2y05B-2mgvA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 2mgv BIFUNCTIONAL
MEMBRANE-ASSOCIATED
PENICILLIN-BINDING
PROTEIN 1A/1B PONA2
(Mycobacterium
tuberculosis) 		6 / 12 ALA A  14
ASP A  13
ASP A  11
VAL A  42
THR A  45
VAL A   7
 None
 1.23A 3el5B-2mgvA:
undetectable		 3el5B-2mgvA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 2mgv BIFUNCTIONAL
MEMBRANE-ASSOCIATED
PENICILLIN-BINDING
PROTEIN 1A/1B PONA2
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  13
VAL A  42
THR A  45
PRO A  47
VAL A   7
 None
 0.92A 3el5B-2mgvA:
undetectable		 3el5B-2mgvA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2mgv BIFUNCTIONAL
MEMBRANE-ASSOCIATED
PENICILLIN-BINDING
PROTEIN 1A/1B PONA2
(Mycobacterium
tuberculosis) 		5 / 8 GLY A  23
ALA A  22
ASP A  21
PRO A  47
THR A  51
 None
 1.29A 4eyrB-2mgvA:
undetectable		 4eyrB-2mgvA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2mgv BIFUNCTIONAL
MEMBRANE-ASSOCIATED
PENICILLIN-BINDING
PROTEIN 1A/1B PONA2
(Mycobacterium
tuberculosis) 		4 / 6 ASP A  13
THR A  45
PRO A  47
VAL A   7
 None
 0.91A 4yoaA-2mgvA:
undetectable		 4yoaA-2mgvA:
19.59