SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mhr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.31A 1v7zA-2mhrA:
undetectable		 1v7zA-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.15A 1v7zA-2mhrA:
undetectable		 1v7zA-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.33A 1v7zB-2mhrA:
undetectable		 1v7zB-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.16A 1v7zB-2mhrA:
undetectable		 1v7zB-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.35A 1v7zC-2mhrA:
undetectable		 1v7zC-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.19A 1v7zC-2mhrA:
undetectable		 1v7zC-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.31A 1v7zD-2mhrA:
undetectable		 1v7zD-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.14A 1v7zD-2mhrA:
undetectable		 1v7zD-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.31A 1v7zE-2mhrA:
undetectable		 1v7zE-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.14A 1v7zE-2mhrA:
undetectable		 1v7zE-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.35A 1v7zF-2mhrA:
undetectable		 1v7zF-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.18A 1v7zF-2mhrA:
undetectable		 1v7zF-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 11 LEU A 118
HIS A  77
HIS A  73
HIS A 106
THR A  56
 None
FEO  A 119 (-3.3A)
FEO  A 119 (-3.5A)
FEO  A 119 ( 3.3A)
None
 1.37A 2dttD-2mhrA:
undetectable
2dttE-2mhrA:
undetectable		 2dttD-2mhrA:
17.89
2dttE-2mhrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 11 HIS A  25
ILE A  28
HIS A  54
HIS A  77
HIS A 106
 FEO  A 119 ( 3.4A)
AZI  A 120 (-4.6A)
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.3A)
FEO  A 119 ( 3.3A)
 1.25A 2zweA-2mhrA:
undetectable
2zweB-2mhrA:
undetectable		 2zweA-2mhrA:
15.41
2zweB-2mhrA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.30A 3a6jA-2mhrA:
undetectable		 3a6jA-2mhrA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.17A 3a6jA-2mhrA:
undetectable		 3a6jA-2mhrA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 10 TYR A   8
HIS A  25
ASP A 111
HIS A  54
ILE A  28
 None
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
FEO  A 119 ( 3.3A)
AZI  A 120 (-4.6A)
 1.47A 3kcxA-2mhrA:
undetectable		 3kcxA-2mhrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 5 LEU A  21
HIS A 106
HIS A  73
HIS A  77
 None
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.5A)
FEO  A 119 (-3.3A)
 0.94A 3kecA-2mhrA:
undetectable		 3kecA-2mhrA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 5 GLU A  12
LYS A  26
LYS A  30
PHE A  33
 None
None
None
SO4  A 124 (-4.5A)
 1.02A 3rv5C-2mhrA:
1.8
3rv5D-2mhrA:
1.9		 3rv5C-2mhrA:
28.35
3rv5D-2mhrA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 6 LEU A  21
HIS A 106
HIS A  73
HIS A  77
 None
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.5A)
FEO  A 119 (-3.3A)
 0.93A 4a7bA-2mhrA:
undetectable		 4a7bA-2mhrA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 7 HIS A  73
HIS A 106
HIS A  25
HIS A  54
 FEO  A 119 (-3.5A)
FEO  A 119 ( 3.3A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 3.3A)
 0.92A 4p6sA-2mhrA:
undetectable		 4p6sA-2mhrA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 7 HIS A  73
HIS A 106
HIS A  25
HIS A  54
 FEO  A 119 (-3.5A)
FEO  A 119 ( 3.3A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 3.3A)
 0.89A 4p6sB-2mhrA:
undetectable		 4p6sB-2mhrA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 6 HIS A  54
HIS A  25
TYR A 114
GLU A  58
 FEO  A 119 ( 3.3A)
FEO  A 119 ( 3.4A)
None
FEO  A 119 (-2.5A)
 1.10A 4pahA-2mhrA:
undetectable		 4pahA-2mhrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 7 HIS A  73
HIS A 106
HIS A  25
HIS A  54
 FEO  A 119 (-3.5A)
FEO  A 119 ( 3.3A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 3.3A)
 0.92A 5i3aB-2mhrA:
undetectable		 5i3aB-2mhrA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 12 ASP A 111
ILE A 107
PHE A  55
LEU A  81
HIS A  54
 FEO  A 119 ( 2.5A)
AZI  A 120 (-4.7A)
AZI  A 120 (-4.5A)
None
FEO  A 119 ( 3.3A)
 1.45A 5nn8A-2mhrA:
undetectable		 5nn8A-2mhrA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 4 HIS A  54
HIS A  25
TYR A 114
GLU A  58
 FEO  A 119 ( 3.3A)
FEO  A 119 ( 3.4A)
None
FEO  A 119 (-2.5A)
 1.10A 5pahA-2mhrA:
undetectable		 5pahA-2mhrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 11 HIS A  25
HIS A  54
HIS A  73
HIS A 106
ASP A  79
 FEO  A 119 ( 3.4A)
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.5A)
FEO  A 119 ( 3.3A)
None
 1.43A 5z0fA-2mhrA:
undetectable
5z0fB-2mhrA:
undetectable		 5z0fA-2mhrA:
16.80
5z0fB-2mhrA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 11 HIS A  25
ILE A  28
HIS A  54
HIS A  77
HIS A 106
 FEO  A 119 ( 3.4A)
AZI  A 120 (-4.6A)
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.3A)
FEO  A 119 ( 3.3A)
 1.20A 5z0gA-2mhrA:
undetectable
5z0gB-2mhrA:
undetectable		 5z0gA-2mhrA:
16.80
5z0gB-2mhrA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 11 HIS A  25
ILE A  28
HIS A  54
HIS A  77
HIS A 106
 FEO  A 119 ( 3.4A)
AZI  A 120 (-4.6A)
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.3A)
FEO  A 119 ( 3.3A)
 1.21A 5z0iA-2mhrA:
undetectable
5z0iB-2mhrA:
undetectable		 5z0iA-2mhrA:
16.80
5z0iB-2mhrA:
17.80