SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		5 / 11 LEU A  88
ALA A 148
LEU A 134
LEU A 136
VAL A 122
 None
 1.25A 1ictA-2miiA:
undetectable
1ictC-2miiA:
undetectable		 1ictA-2miiA:
20.00
1ictC-2miiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		5 / 11 LYS A 131
LEU A 127
ALA A 130
ALA A 157
VAL A  89
 None
 1.22A 1ictA-2miiA:
undetectable
1ictC-2miiA:
undetectable		 1ictA-2miiA:
20.00
1ictC-2miiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		5 / 12 GLY A 150
VAL A 122
LEU A 142
LEU A  88
LEU A 136
 None
 1.17A 1mx1C-2miiA:
undetectable		 1mx1C-2miiA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		4 / 7 LEU A 178
VAL A  81
GLY A  80
GLY A  77
 None
 0.78A 2wd9A-2miiA:
undetectable		 2wd9A-2miiA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		4 / 5 PRO A  57
THR A  96
VAL A 169
GLY A  98
 None
 1.17A 3elzA-2miiA:
undetectable		 3elzA-2miiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		3 / 3 TYR A 159
THR A  82
GLU A 185
 None
 0.80A 4df3A-2miiA:
undetectable		 4df3A-2miiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		3 / 3 TYR A 159
THR A  82
GLU A 185
 None
 0.82A 4df3B-2miiA:
undetectable		 4df3B-2miiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		5 / 9 LEU A 174
PRO A 172
ASN A  94
ASN A  93
SER A 164
 None
 1.30A 4omwD-2miiA:
0.0		 4omwD-2miiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		5 / 9 VAL A  89
LEU A 109
GLY A 190
GLN A 177
VAL A  72
 None
 1.22A 6czmA-2miiA:
undetectable
6czmB-2miiA:
undetectable		 6czmA-2miiA:
20.73
6czmB-2miiA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		5 / 9 VAL A  89
LEU A 109
GLY A 190
GLN A 177
VAL A  72
 None
 1.12A 6czmB-2miiA:
undetectable
6czmC-2miiA:
undetectable		 6czmB-2miiA:
20.73
6czmC-2miiA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB
(Escherichia
coli) 		5 / 10 VAL A  89
LEU A 109
GLY A 190
GLN A 177
VAL A  72
 None
 1.11A 6czmE-2miiA:
undetectable
6czmF-2miiA:
undetectable		 6czmE-2miiA:
20.73
6czmF-2miiA:
20.73