SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mjh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TLS_A_C2FA266_0 (THYMIDYLATE SYNTHASE)	2mjh	FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1 (Caenorhabditis elegans)	5 / 12	HIS A 261 SER A 251 LEU A 302 LEU A 226 GLY A 223	None None None A B 22 ( 3.6A) U B 20 ( 3.1A)	1.10A	1tlsA-2mjhA: undetectable	1tlsA-2mjhA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TLS_B_C2FB266_0 (THYMIDYLATE SYNTHASE)	2mjh	FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1 (Caenorhabditis elegans)	5 / 12	HIS A 261 SER A 251 LEU A 302 LEU A 226 GLY A 223	None None None A B 22 ( 3.6A) U B 20 ( 3.1A)	1.08A	1tlsB-2mjhA: undetectable	1tlsB-2mjhA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TSN_A_C2FA266_0 (THYMIDYLATE SYNTHASE)	2mjh	FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1 (Caenorhabditis elegans)	5 / 12	HIS A 261 SER A 251 LEU A 302 LEU A 226 GLY A 223	None None None A B 22 ( 3.6A) U B 20 ( 3.1A)	1.10A	1tsnA-2mjhA: undetectable	1tsnA-2mjhA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOX_A_D16A301_1 (THYMIDYLATE SYNTHASE)	2mjh	FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1 (Caenorhabditis elegans)	5 / 12	HIS A 261 SER A 251 LEU A 302 LEU A 226 GLY A 223	None None None A B 22 ( 3.6A) U B 20 ( 3.1A)	1.02A	4foxA-2mjhA: undetectable	4foxA-2mjhA: 17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOX_C_D16C301_1 (THYMIDYLATE SYNTHASE)	2mjh	FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1 (Caenorhabditis elegans)	5 / 11	HIS A 261 SER A 251 LEU A 302 LEU A 226 GLY A 223	None None None A B 22 ( 3.6A) U B 20 ( 3.1A)	0.98A	4foxC-2mjhA: undetectable	4foxC-2mjhA: 17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOX_G_D16G301_1 (THYMIDYLATE SYNTHASE)	2mjh	FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1 (Caenorhabditis elegans)	5 / 12	HIS A 261 SER A 251 LEU A 302 LEU A 226 GLY A 223	None None None A B 22 ( 3.6A) U B 20 ( 3.1A)	1.01A	4foxG-2mjhA: undetectable	4foxG-2mjhA: 17.49

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1TLS_A_C2FA266_0","THYMIDYLATE SYNTHASE","2mjh","FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1","Caenorhabditis elegans",5,"HIS A 261;SER A 251;LEU A 302;LEU A 226;GLY A 223","None;None;None;  A B  22 ( 3.6A);  U B  20 ( 3.1A)","1.10A","1tlsA-2mjhA:undetectable","1tlsA-2mjhA:19.29"],["1TLS_B_C2FB266_0","THYMIDYLATE SYNTHASE","2mjh","FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1","Caenorhabditis elegans",5,"HIS A 261;SER A 251;LEU A 302;LEU A 226;GLY A 223","None;None;None;  A B  22 ( 3.6A);  U B  20 ( 3.1A)","1.08A","1tlsB-2mjhA:undetectable","1tlsB-2mjhA:19.29"],["1TSN_A_C2FA266_0","THYMIDYLATE SYNTHASE","2mjh","FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1","Caenorhabditis elegans",5,"HIS A 261;SER A 251;LEU A 302;LEU A 226;GLY A 223","None;None;None;  A B  22 ( 3.6A);  U B  20 ( 3.1A)","1.10A","1tsnA-2mjhA:undetectable","1tsnA-2mjhA:19.29"],["4FOX_A_D16A301_1","THYMIDYLATE SYNTHASE","2mjh","FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1","Caenorhabditis elegans",5,"HIS A 261;SER A 251;LEU A 302;LEU A 226;GLY A 223","None;None;None;  A B  22 ( 3.6A);  U B  20 ( 3.1A)","1.02A","4foxA-2mjhA:undetectable","4foxA-2mjhA:17.49"],["4FOX_C_D16C301_1","THYMIDYLATE SYNTHASE","2mjh","FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1","Caenorhabditis elegans",5,"HIS A 261;SER A 251;LEU A 302;LEU A 226;GLY A 223","None;None;None;  A B  22 ( 3.6A);  U B  20 ( 3.1A)","0.98A","4foxC-2mjhA:undetectable","4foxC-2mjhA:17.49"],["4FOX_G_D16G301_1","THYMIDYLATE SYNTHASE","2mjh","FEMALE GERMLINE-SPECIFIC TUMOR SUPPRESSOR GLD-1","Caenorhabditis elegans",5,"HIS A 261;SER A 251;LEU A 302;LEU A 226;GLY A 223","None;None;None;  A B  22 ( 3.6A);  U B  20 ( 3.1A)","1.01A","4foxG-2mjhA:undetectable","4foxG-2mjhA:17.49"]]