SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 150
SER A 153
ASN A  98
ILE A 101
 None
 0.92A 1yc2A-2mjpA:
undetectable		 1yc2A-2mjpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 150
SER A 153
ASN A  98
ILE A 101
 None
 0.86A 1yc5A-2mjpA:
undetectable		 1yc5A-2mjpA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 113
PHE A  76
GLY A  86
THR A  87
LEU A  81
 None
 1.21A 2zifA-2mjpA:
undetectable		 2zifA-2mjpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 113
PHE A  76
GLY A  86
THR A  87
LEU A  81
 None
 1.21A 2zifB-2mjpA:
undetectable		 2zifB-2mjpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A 191
GLU A 183
ILE A  27
ASP A  30
 None
 1.05A 4xjeA-2mjpA:
undetectable		 4xjeA-2mjpA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ASP A 152
PHE A 155
PHE A 164
VAL A 134
 ANP  A 500 (-3.5A)
None
None
None
 1.16A 5a1rA-2mjpA:
undetectable		 5a1rA-2mjpA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  28
ILE A  21
PHE A 185
ILE A  70
ILE A  11
 None
 0.94A 6ebzA-2mjpA:
undetectable		 6ebzA-2mjpA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  28
ILE A  21
PHE A 185
ILE A  70
ILE A  11
 None
 0.92A 6ebzB-2mjpA:
undetectable		 6ebzB-2mjpA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  28
ILE A  21
PHE A 185
ILE A  70
ILE A  11
 None
 0.95A 6ebzC-2mjpA:
undetectable		 6ebzC-2mjpA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  28
ILE A  21
PHE A 185
ILE A  70
ILE A  11
 None
 0.90A 6ebzD-2mjpA:
undetectable		 6ebzD-2mjpA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  28
ILE A  21
PHE A 185
ILE A  70
ILE A  11
 None
 0.85A 6gp2A-2mjpA:
undetectable		 6gp2A-2mjpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2mjp PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  28
ILE A  21
PHE A 185
ILE A  70
ILE A  11
 None
 0.84A 6gp2B-2mjpA:
undetectable		 6gp2B-2mjpA:
21.35