SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mki'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens) 		3 / 3 GLY A 198
ASP A 194
ASN A 224
 None
 0.55A 1vq1A-2mkiA:
undetectable		 1vq1A-2mkiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens) 		4 / 5 PRO A 153
VAL A  67
VAL A 121
ILE A 125
 None
 1.05A 1z2bC-2mkiA:
undetectable		 1z2bC-2mkiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 GLY A  70
GLY A  71
GLN A 150
VAL A 149
ILE A  81
 U  B   2 ( 3.9A)
C  B   1 ( 2.7A)
U  B   2 ( 2.8A)
None
None
 1.09A 3h52B-2mkiA:
undetectable		 3h52B-2mkiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens) 		3 / 3 LEU A 113
LEU A  91
ARG A  87
 None
 0.70A 3hcnB-2mkiA:
undetectable		 3hcnB-2mkiA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens) 		4 / 7 LEU A 169
ARG A 219
THR A 174
ALA A 221
 None
 0.92A 3mbgA-2mkiA:
undetectable
3mbgB-2mkiA:
undetectable		 3mbgA-2mkiA:
19.21
3mbgB-2mkiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 PRO A  73
ILE A 151
LEU A  72
VAL A 139
PHE A  85
 None
 1.29A 5bykA-2mkiA:
undetectable		 5bykA-2mkiA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 VAL A 250
ALA A 230
ALA A 231
VAL A 237
GLY A 199
 None
 1.06A 5igjA-2mkiA:
undetectable		 5igjA-2mkiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 VAL A 250
ALA A 230
ALA A 231
VAL A 237
GLY A 199
 None
 1.04A 5igtA-2mkiA:
undetectable		 5igtA-2mkiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 PRO A  73
ILE A 151
LEU A  72
VAL A 139
PHE A  85
 None
 1.28A 5tiwB-2mkiA:
undetectable		 5tiwB-2mkiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 10 PRO A  73
ILE A 151
LEU A  72
VAL A 139
PHE A  85
 None
 1.31A 5tixB-2mkiA:
undetectable		 5tixB-2mkiA:
20.97