SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ml2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 12 ALA A  97
LEU A 154
LEU A  98
ILE A  83
LEU A  45
 None
 0.92A 2aclA-2ml2A:
undetectable
2aclE-2ml2A:
undetectable		 2aclA-2ml2A:
22.92
2aclE-2ml2A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 12 GLY A  24
GLY A  38
GLY A  41
THR A  55
ILE A  83
 CA  A 202 ( 4.8A)
CA  A 202 (-3.9A)
CA  A 204 (-4.4A)
None
None
 0.96A 2oxtA-2ml2A:
undetectable		 2oxtA-2ml2A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 12 GLY A  24
GLY A  56
GLY A  38
LEU A  36
GLU A  58
 CA  A 202 ( 4.8A)
CA  A 204 (-4.4A)
CA  A 202 (-3.9A)
None
None
 1.02A 3kkzB-2ml2A:
undetectable		 3kkzB-2ml2A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 8 GLY A  48
GLY A  47
ILE A  83
LEU A  93
VAL A 138
 CA  A 203 (-4.2A)
CA  A 203 (-4.6A)
None
None
None
 1.03A 3v1nA-2ml2A:
undetectable		 3v1nA-2ml2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		4 / 8 GLU A  69
ARG A  73
GLY A 133
ARG A 134
 None
 1.06A 4fgzA-2ml2A:
undetectable
4fgzB-2ml2A:
undetectable		 4fgzA-2ml2A:
20.07
4fgzB-2ml2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		4 / 5 SER A  80
ARG A  51
LEU A  82
ASP A  52
 None
None
None
CA  A 203 ( 2.6A)
 1.07A 4ifxA-2ml2A:
undetectable		 4ifxA-2ml2A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		4 / 5 SER A  80
ARG A  51
LEU A  82
ASP A  52
 None
None
None
CA  A 203 ( 2.6A)
 1.04A 4ig1A-2ml2A:
undetectable		 4ig1A-2ml2A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		6 / 12 THR A  21
GLY A  24
GLY A  41
GLY A  40
LEU A  22
ALA A   4
 None
CA  A 202 ( 4.8A)
CA  A 204 (-4.4A)
CA  A 204 ( 4.2A)
None
None
 1.32A 5c0oF-2ml2A:
undetectable		 5c0oF-2ml2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		4 / 6 SER A 114
GLU A 137
ARG A  51
ARG A  73
 None
 1.31A 5zw4A-2ml2A:
undetectable		 5zw4A-2ml2A:
17.86