SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ml8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 210
LEU A 151
LEU A 206
LEU A 175
ILE A 186
 None
 1.02A 1ha2A-2ml8A:
undetectable		 1ha2A-2ml8A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 151
LEU A 154
VAL A 155
ILE A 186
 None
 0.83A 4oj4A-2ml8A:
undetectable		 4oj4A-2ml8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 214
PHE A 217
PHE A 194
LEU A 190
 None
 1.10A 5z84P-2ml8A:
undetectable
5z84W-2ml8A:
undetectable		 5z84P-2ml8A:
20.75
5z84W-2ml8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 214
PHE A 217
PHE A 194
LEU A 190
 None
 1.11A 5z85P-2ml8A:
undetectable
5z85W-2ml8A:
undetectable		 5z85P-2ml8A:
20.75
5z85W-2ml8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 214
PHE A 217
PHE A 194
LEU A 190
 None
 1.09A 5z86P-2ml8A:
undetectable
5z86W-2ml8A:
undetectable		 5z86P-2ml8A:
20.75
5z86W-2ml8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 214
PHE A 217
PHE A 194
LEU A 190
 None
 1.06A 5zcoP-2ml8A:
undetectable
5zcoW-2ml8A:
undetectable		 5zcoP-2ml8A:
20.75
5zcoW-2ml8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 214
PHE A 217
PHE A 194
LEU A 190
 None
 1.11A 5zcpC-2ml8A:
undetectable
5zcpJ-2ml8A:
undetectable		 5zcpC-2ml8A:
20.75
5zcpJ-2ml8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 214
PHE A 217
PHE A 194
LEU A 190
 None
 1.09A 5zcpP-2ml8A:
undetectable
5zcpW-2ml8A:
undetectable		 5zcpP-2ml8A:
20.75
5zcpW-2ml8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 187
THR A 197
GLU A 202
LEU A 206
LEU A 209
 None
 1.19A 6gbnC-2ml8A:
undetectable		 6gbnC-2ml8A:
17.24