SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mnj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2mnj PROTEIN INTERACTING
WITH HSP90 1
TPR
REPEAT-CONTAINING
PROTEIN ASSOCIATED
WITH HSP90
(Saccharomyces
cerevisiae) 		4 / 8 GLY A   1
ILE B  74
VAL A   6
TYR B  68
 None
 0.85A 2yoeB-2mnjA:
undetectable
2yoeC-2mnjA:
undetectable		 2yoeB-2mnjA:
5.86
2yoeC-2mnjA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2mnj TPR
REPEAT-CONTAINING
PROTEIN ASSOCIATED
WITH HSP90
PROTEIN INTERACTING
WITH HSP90 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 TYR B 108
THR B 106
GLU A  15
 None
 0.79A 4df3A-2mnjB:
undetectable		 4df3A-2mnjB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2mnj TPR
REPEAT-CONTAINING
PROTEIN ASSOCIATED
WITH HSP90
PROTEIN INTERACTING
WITH HSP90 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 TYR B 108
THR B 106
GLU A  15
 None
 0.78A 4df3B-2mnjB:
undetectable		 4df3B-2mnjB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2mnj PROTEIN INTERACTING
WITH HSP90 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE B  50
ARG B  40
LEU B  48
ILE B  83
 None
 0.82A 4zvcA-2mnjB:
undetectable
4zvcB-2mnjB:
undetectable		 4zvcA-2mnjB:
21.24
4zvcB-2mnjB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2mnj PROTEIN INTERACTING
WITH HSP90 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE B  83
ILE B  50
ARG B  40
LEU B  48
 None
 0.79A 4zvcA-2mnjB:
undetectable
4zvcB-2mnjB:
undetectable		 4zvcA-2mnjB:
21.24
4zvcB-2mnjB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2mnj PROTEIN INTERACTING
WITH HSP90 1
(Saccharomyces
cerevisiae) 		3 / 3 ILE B  83
ILE B  98
MET B  38
 None
 0.63A 5i9yA-2mnjB:
undetectable		 5i9yA-2mnjB:
15.05