SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mpf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2mpf POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Homo
sapiens) 		4 / 8 LEU A 642
PHE A 552
LEU A 544
ALA A 548
 None
 0.83A 1fiqC-2mpfA:
undetectable		 1fiqC-2mpfA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 2mpf POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Homo
sapiens) 		5 / 12 LEU A 633
MET A 581
LEU A 560
THR A 558
THR A 554
 None
 1.47A 3thrA-2mpfA:
0.0
3thrB-2mpfA:
undetectable
3thrC-2mpfA:
0.0
3thrD-2mpfA:
undetectable		 3thrA-2mpfA:
19.23
3thrB-2mpfA:
19.23
3thrC-2mpfA:
19.23
3thrD-2mpfA:
19.23