SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBK_A_RAPA225_1
(FKBP25)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		6 / 12 ASP A 146
LEU A 162
GLY A 169
VAL A 171
ILE A 172
TRP A 175
 None
 1.24A 1pbkA-2mphA:
18.1		 1pbkA-2mphA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBK_A_RAPA225_1
(FKBP25)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		7 / 12 TYR A 135
LEU A 162
GLY A 169
VAL A 171
ILE A 172
TRP A 175
PHE A 216
 None
 1.24A 1pbkA-2mphA:
18.1		 1pbkA-2mphA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		5 / 9 LEU A 162
VAL A 171
ILE A 172
TRP A 175
PHE A 216
 None
 1.31A 1q6iA-2mphA:
13.7		 1q6iA-2mphA:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		5 / 9 TYR A 135
LEU A 162
VAL A 171
ILE A 172
TRP A 175
 None
 1.00A 1q6iA-2mphA:
13.7		 1q6iA-2mphA:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		5 / 10 ASP A 146
LEU A 162
VAL A 171
ILE A 172
TRP A 175
 None
 1.21A 3kz7A-2mphA:
18.3		 3kz7A-2mphA:
95.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		6 / 10 TYR A 135
LEU A 162
VAL A 171
ILE A 172
TRP A 175
PHE A 216
 None
 1.27A 3kz7A-2mphA:
18.3		 3kz7A-2mphA:
95.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		5 / 12 TYR A 135
LEU A 179
PHE A 216
PHE A 145
VAL A 218
 None
 1.32A 4c9wA-2mphA:
0.0		 4c9wA-2mphA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		5 / 10 ASP A 146
VAL A 171
ILE A 172
TRP A 175
PHE A 216
 None
 1.41A 4laxA-2mphA:
16.9		 4laxA-2mphA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		5 / 11 ASP A 146
LEU A 162
VAL A 171
ILE A 172
TRP A 175
 None
 1.13A 5d75A-2mphA:
18.0		 5d75A-2mphA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		5 / 11 TYR A 135
LEU A 162
VAL A 171
ILE A 172
TRP A 175
 None
 0.96A 5d75A-2mphA:
18.0		 5d75A-2mphA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		5 / 11 TYR A 135
LEU A 162
VAL A 171
ILE A 172
TRP A 175
 None
 1.01A 5gpgA-2mphA:
18.1		 5gpgA-2mphA:
79.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		5 / 10 TYR A 135
VAL A 171
ILE A 172
TRP A 175
LEU A 214
 None
 0.95A 5hw8C-2mphA:
15.4
5hw8H-2mphA:
13.2		 5hw8C-2mphA:
26.82
5hw8H-2mphA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
(Homo
sapiens) 		4 / 8 PHE A  28
LEU A  66
ALA A  62
LEU A  43
 None
 0.85A 5y7pE-2mphA:
undetectable		 5y7pE-2mphA:
21.60