SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mpu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2mpu RBP1
(Hordeum
vulgare) 		5 / 8 THR A  20
GLY A  24
GLY A  14
LEU A  16
GLY A  53
 None
 1.41A 1jhqA-2mpuA:
undetectable		 1jhqA-2mpuA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2mpu RBP1
(Hordeum
vulgare) 		5 / 12 GLY A  24
THR A  20
PHE A  29
ARG A  78
LEU A  75
 None
 1.36A 3iv6C-2mpuA:
undetectable		 3iv6C-2mpuA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2mpu RBP1
(Hordeum
vulgare) 		5 / 12 GLY A  24
THR A  20
PHE A  29
ARG A  78
LEU A  75
 None
 1.29A 3iv6D-2mpuA:
undetectable		 3iv6D-2mpuA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2mpu RBP1
(Hordeum
vulgare) 		5 / 9 THR A  20
GLY A  24
GLY A  14
LEU A  16
GLY A  53
 None
 1.35A 4kqiA-2mpuA:
undetectable		 4kqiA-2mpuA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2mpu RBP1
(Hordeum
vulgare) 		3 / 3 ASP A  21
VAL A  55
ASN A  42
 None
 0.78A 4lmnA-2mpuA:
undetectable		 4lmnA-2mpuA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2mpu RBP1
(Hordeum
vulgare) 		3 / 3 PHE A  52
ILE A  41
ASP A  37
 None
 0.74A 5cswA-2mpuA:
undetectable		 5cswA-2mpuA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2mpu RBP1
(Hordeum
vulgare) 		3 / 3 PHE A  52
ILE A  41
ASP A  37
 None
 0.69A 5cswB-2mpuA:
undetectable		 5cswB-2mpuA:
17.25