SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ILQ_C_ACAC7_1 (INTERLEUKIN-8 PRECURSOR INTERLEUKIN-8 RECEPTOR A)	2mq1	E3 UBIQUITIN-PROTEIN LIGASE HAKAI (Mus musculus)	4 / 6	HIS A 22 PHE A 24 ASP A 5 PRO A 41	ZN A 102 (-2.8A) None None None	1.01A	1ilqA-2mq1A: undetectable 1ilqC-2mq1A: undetectable	1ilqA-2mq1A: 22.35 1ilqC-2mq1A: 10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QPK_A_CUA601_0 (LACCASE-1)	2mq1	E3 UBIQUITIN-PROTEIN LIGASE HAKAI (Mus musculus)	4 / 5	HIS A 80 CYH A 61 ILE A 63 HIS A 85	ZN A 103 (-3.1A) ZN A 103 (-2.3A) ZN A 103 ( 4.9A) ZN A 103 (-2.9A)	1.41A	3qpkA-2mq1A: undetectable	3qpkA-2mq1A: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QPK_B_CUB601_0 (LACCASE-1)	2mq1	E3 UBIQUITIN-PROTEIN LIGASE HAKAI (Mus musculus)	4 / 4	HIS A 80 CYH A 61 ILE A 63 HIS A 85	ZN A 103 (-3.1A) ZN A 103 (-2.3A) ZN A 103 ( 4.9A) ZN A 103 (-2.9A)	1.38A	3qpkB-2mq1A: undetectable	3qpkB-2mq1A: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HRQ_K_IPHK101_0 (INSULIN A-CHAIN INSULIN B-CHAIN)	2mq1	E3 UBIQUITIN-PROTEIN LIGASE HAKAI (Mus musculus)	4 / 6	VAL A 1 CYH A 4 CYH A 25 HIS A 22	None ZN A 101 (-2.5A) ZN A 101 (-2.2A) ZN A 102 (-2.8A)	1.27A	5hrqH-2mq1A: undetectable 5hrqK-2mq1A: undetectable 5hrqL-2mq1A: undetectable	5hrqH-2mq1A: 8.99 5hrqK-2mq1A: 17.33 5hrqL-2mq1A: 8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MEJ_A_CUA504_0 (LACCASE 2)	2mq1	E3 UBIQUITIN-PROTEIN LIGASE HAKAI (Mus musculus)	4 / 4	HIS A 80 CYH A 61 ILE A 81 HIS A 85	ZN A 103 (-3.1A) ZN A 103 (-2.3A) None ZN A 103 (-2.9A)	1.50A	5mejA-2mq1A: undetectable	5mejA-2mq1A: 9.85

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ILQ_C_ACAC7_1","INTERLEUKIN-8 PRECURSOR;INTERLEUKIN-8 RECEPTOR A","2mq1","E3 UBIQUITIN-PROTEIN LIGASE HAKAI","Mus musculus",4,"HIS A  22;PHE A  24;ASP A   5;PRO A  41"," ZN A 102 (-2.8A);None;None;None","1.01A","1ilqA-2mq1A:undetectable;1ilqC-2mq1A:undetectable","1ilqA-2mq1A:22.35;1ilqC-2mq1A:10.11"],["3QPK_A_CUA601_0","LACCASE-1","2mq1","E3 UBIQUITIN-PROTEIN LIGASE HAKAI","Mus musculus",4,"HIS A  80;CYH A  61;ILE A  63;HIS A  85"," ZN A 103 (-3.1A); ZN A 103 (-2.3A); ZN A 103 ( 4.9A); ZN A 103 (-2.9A)","1.41A","3qpkA-2mq1A:undetectable","3qpkA-2mq1A:8.96"],["3QPK_B_CUB601_0","LACCASE-1","2mq1","E3 UBIQUITIN-PROTEIN LIGASE HAKAI","Mus musculus",4,"HIS A  80;CYH A  61;ILE A  63;HIS A  85"," ZN A 103 (-3.1A); ZN A 103 (-2.3A); ZN A 103 ( 4.9A); ZN A 103 (-2.9A)","1.38A","3qpkB-2mq1A:undetectable","3qpkB-2mq1A:8.96"],["5HRQ_K_IPHK101_0","INSULIN A-CHAIN;INSULIN B-CHAIN","2mq1","E3 UBIQUITIN-PROTEIN LIGASE HAKAI","Mus musculus",4,"VAL A   1;CYH A   4;CYH A  25;HIS A  22","None; ZN A 101 (-2.5A); ZN A 101 (-2.2A); ZN A 102 (-2.8A)","1.27A","5hrqH-2mq1A:undetectable;5hrqK-2mq1A:undetectable;5hrqL-2mq1A:undetectable","5hrqH-2mq1A:8.99;5hrqK-2mq1A:17.33;5hrqL-2mq1A:8.99"],["5MEJ_A_CUA504_0","LACCASE 2","2mq1","E3 UBIQUITIN-PROTEIN LIGASE HAKAI","Mus musculus",4,"HIS A  80;CYH A  61;ILE A  81;HIS A  85"," ZN A 103 (-3.1A); ZN A 103 (-2.3A);None; ZN A 103 (-2.9A)","1.50A","5mejA-2mq1A:undetectable","5mejA-2mq1A:9.85"]]