SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mqa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2mqa MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 4 SER A 112
ILE A 111
VAL A  58
THR A 128
 None
 1.05A 1u70A-2mqaA:
undetectable		 1u70A-2mqaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2mqa MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		5 / 12 ILE A 101
ASN A  95
LEU A 105
ALA A 106
VAL A  54
 None
 1.14A 1xdkA-2mqaA:
undetectable		 1xdkA-2mqaA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2mqa MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		5 / 11 ALA A  47
ALA A  51
GLY A  78
GLY A  84
ILE A  87
 None
 0.85A 2x1lA-2mqaA:
undetectable		 2x1lA-2mqaA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2mqa MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		5 / 12 ALA A  47
ALA A  51
GLY A  78
GLY A  84
ILE A  87
 None
 0.82A 2x1lB-2mqaA:
undetectable		 2x1lB-2mqaA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2mqa MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		5 / 11 ALA A  47
ALA A  51
GLY A  78
GLY A  84
ILE A  87
 None
 0.87A 2x1lC-2mqaA:
undetectable		 2x1lC-2mqaA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2mqa MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 8 LEU A  29
SER A  30
LEU A  83
ILE A  38
 None
 0.89A 3ln1A-2mqaA:
undetectable		 3ln1A-2mqaA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2mqa MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 7 LEU A  29
SER A  30
LEU A  83
ILE A  38
 None
 0.89A 3ln1B-2mqaA:
undetectable		 3ln1B-2mqaA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 2mqa MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		5 / 12 ALA A  47
PHE A  20
ALA A 116
ALA A 119
THR A  52
 None
 1.23A 5tl8A-2mqaA:
undetectable		 5tl8A-2mqaA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2mqa MINOR AMPULLATE
FIBROIN 1
(Nephila
antipodiana) 		4 / 6 SER A  81
GLY A  84
ILE A  38
PHE A  34
 None
 0.80A 6f8cA-2mqaA:
undetectable		 6f8cA-2mqaA:
16.11