SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2mqe OMPA DOMAIN PROTEIN
TRANSMEMBRANE
REGION-CONTAINING
PROTEIN
(Escherichia
coli) 		4 / 8 SER A 233
VAL A 235
SER A 275
ASP A 272
 None
 1.25A 1hwiB-2mqeA:
undetectable		 1hwiB-2mqeA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2mqe OMPA DOMAIN PROTEIN
TRANSMEMBRANE
REGION-CONTAINING
PROTEIN
(Escherichia
coli) 		4 / 4 GLU A 254
GLY A 280
THR A 240
GLU A 281
 None
 1.13A 3e9xA-2mqeA:
undetectable		 3e9xA-2mqeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2mqe OMPA DOMAIN PROTEIN
TRANSMEMBRANE
REGION-CONTAINING
PROTEIN
(Escherichia
coli) 		5 / 10 ILE A 316
LEU A 264
VAL A 236
VAL A 260
LEU A 217
 None
 0.90A 3gwxA-2mqeA:
undetectable		 3gwxA-2mqeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2mqe OMPA DOMAIN PROTEIN
TRANSMEMBRANE
REGION-CONTAINING
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 316
LEU A 264
VAL A 236
VAL A 260
LEU A 217
 None
 0.95A 3gwxB-2mqeA:
undetectable		 3gwxB-2mqeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2mqe OMPA DOMAIN PROTEIN
TRANSMEMBRANE
REGION-CONTAINING
PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 248
ASP A 241
ASP A 301
 None
 0.74A 3ou6B-2mqeA:
undetectable		 3ou6B-2mqeA:
20.91